(Q21113314)

hierarchical database ID heuristic

Transporter Classification Database ID

1.A.9.5.2

Neurotransmitter-gated ion-channel ligand-binding domain superfamily

1 October 2019

part of

1 reference

Gamma-aminobutyric-acid A receptor, beta subunit

1 reference

Neurotransmitter-gated ion-channel transmembrane domain superfamily

1 reference

Transporter Classification Database ID

GABAA receptor

1 reference

1.A.9.5.2

2 October 2019

hierarchical database ID heuristic

Neurotransmitter-gated ion-channel transmembrane domain, protein family

1 reference

inferred from protein domain or family

Neurotransmitter-gated ion-channel ligand-binding domain, protein family

1 reference

inferred from protein domain or family

Neurotransmitter-gated ion-channel, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

inhibitory extracellular ligand-gated ion channel activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

ion channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

1 reference

8 April 2019

GABA receptor activity

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47870&geneProductId=UniProtKB:P47870

chloride channel activity

ISS

extracellular ligand-gated ion channel activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47870&geneProductId=UniProtKB:P47870

1 reference

31 October 2017

GABA-A receptor activity

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

transmembrane signaling receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

1 reference

8 April 2019

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

cell component

cytosol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

GABA-A receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

postsynaptic membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

1 reference

8 April 2019

membrane

plasma membrane

integral component of plasma membrane

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47870&geneProductId=UniProtKB:P47870

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47870&geneProductId=UniProtKB:P47870

31 October 2017

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47870&geneProductId=UniProtKB:P47870

synapse

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47870&geneProductId=UniProtKB:P47870

1 reference

31 October 2017

chloride channel complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

1 reference

8 April 2019

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

1 reference

8 April 2019

GABA receptor complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

extracellular exosome

1 reference

31 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47870&geneProductId=UniProtKB:P47870

cytoplasmic vesicle membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

1 reference

8 April 2019

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

8 April 2019

A de novo missense mutation of GABRB2 causes early myoclonic encephalopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

integral component of plasma membrane

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

neuron projection

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

extracellular exosome

HDA

1 reference

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

HDA

GABA-ergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

integral component of postsynaptic specialization membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

gamma-aminobutyric acid signaling pathway

biological process

1 reference

31 October 2017

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47870&geneProductId=UniProtKB:P47870

negative regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

chemical synaptic transmission

1 reference

31 October 2017

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47870&geneProductId=UniProtKB:P47870

cochlea development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

neuron development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

hearing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

inner ear receptor cell development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

chloride transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

1 reference

8 April 2019

innervation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

negative regulation of neuron death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

gamma-aminobutyric acid signaling pathway

IMP

regulation of membrane potential

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

nervous system process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

regulation of postsynaptic membrane potential

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

inhibitory synapse assembly

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

8 April 2019

Inhibitory synapse formation in a co-culture model incorporating GABAergic medium spiny neurons and HEK293 cells stably expressing GABAA receptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

8 April 2019

GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47870

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4051

language of work or name

English

17 August 2016

metharbital

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL450

triclofos

positive modulator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201317

butalbital

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL454

chlordiazepoxide

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451

diazepam

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL12

prazepam

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL969

zopiclone

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL135400

topiramate

positive modulator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL220492

clotiazepam

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1697737

allopregnanolone

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL38856

chlordiazepoxide hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200703

clorazepate dipotassium

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2096631

methohexital sodium

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL30219

pentobarbital sodium

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL971

has part(s)

Neurotransmitter-gated ion-channel transmembrane domain

1 reference

Neurotransmitter-gated ion-channel ligand-binding domain

1 reference

Neurotransmitter-gated ion-channel, conserved site

1 reference

Transporter Classification Database ID

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1.A.9.5.2

2 references

Transporter Classification database

13 March 2020

Transporter Classification database