Wikidata

(Q21113813)

English

Discs large MAGUK scaffold protein 1

mammalian protein found in Homo sapiens

  • discs large homolog 1, scribble cell polarity complex component
  • SAP97
  • discs, large homolog 1 transcript variant 6-v1
  • discs, large homolog 1 transcript variant 6-v2
  • hDlg
  • DLG1
  • presynaptic protein SAP97
  • disks large homolog 1
  • dJ1061C18.1.1
  • synapse-associated protein 97
  • SAP-97
  • Discs Large Homolog 1 Protein
In more languages
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No label defined

No description defined

Statements

part of
molecular function
protein binding
determination method or standard
IPI
25 references
retrieved
8 April 2019
stated in
GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes
GOA
curator
UniProt
UniProt protein ID
Q12959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants
GOA
curator
UniProt
UniProt protein ID
Q12959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein
GOA
curator
UniProt
UniProt protein ID
Q12959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.
GOA
curator
UniProt
UniProt protein ID
Q12959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis
GOA
curator
UniProt
UniProt protein ID
Q12959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase
GOA
curator
UniProt
UniProt protein ID
Q12959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells
GOA
curator
UniProt
UniProt protein ID
Q12959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain
GOA
curator
UniProt
UniProt protein ID
Q12959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity
GOA
curator
SynGO
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteome-wide analysis of phospho-regulated PDZ domain interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Association of cottontail rabbit papillomavirus E6 oncoproteins with the hDlg/SAP97 tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Solution structure of the hDlg/SAP97 PDZ2 domain and its mechanism of interaction with HPV-18 papillomavirus E6 protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of SAP97 as an intracellular binding partner of TACE
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
The multiple-specificity landscape of modular peptide recognition domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
retrieved
8 April 2019
stated in
Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959
determination method or standard
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
D000074288
subject named as
Discs Large Homolog 1 Protein
0 references
RefSeq protein ID
Ensembl protein ID
 
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