(Q21115043)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08908

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signal transducer activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908

G protein-coupled serotonin receptor activity

5 references

16 July 2018

Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908

16 July 2018

Role of glycosphingolipids in the function of human serotonin₁A receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908

16 July 2018

Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908

2 references

8 April 2019

Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2

GOA

curator

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

8 April 2019

Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

neurotransmitter receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

receptor-receptor interaction

1 reference

8 April 2019

Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2

GOA

curator

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

G protein-coupled receptor activity

G protein-coupled serotonin receptor activity

6 references

8 April 2019

Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

8 April 2019

Role of glycosphingolipids in the function of human serotonin₁A receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

8 April 2019

Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

2 references

integral component of plasma membrane

3 references

16 July 2018

The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908

16 July 2018

Role of glycosphingolipids in the function of human serotonin₁A receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908

integral component of plasma membrane

4 references

8 April 2019

The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

8 April 2019

Role of glycosphingolipids in the function of human serotonin₁A receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

G protein-coupled receptor signaling pathway

biological process

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

8 April 2019

Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

8 April 2019

Role of glycosphingolipids in the function of human serotonin₁A receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

regulation of behavior

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

adenylate cyclase-inhibiting serotonin receptor signaling pathway

1 reference

16 July 2018

Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908

positive regulation of cell population proliferation

1 reference

8 April 2019

Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

regulation of hormone secretion

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

adenylate cyclase-inhibiting serotonin receptor signaling pathway

chemical synaptic transmission

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908

physically interacts with

1 reference

8182

17 August 2016

1 reference

7191

17 August 2016

1 reference

8434

17 August 2016

1 reference

8436

17 August 2016

1 reference

8435

17 August 2016

1 reference

3

17 August 2016

5-carboxamidotryptamine

has use

agonist

1 reference

4

17 August 2016

1 reference

5

(+/-)-8-hydroxy-2-(di-N-propylamino)tetralin

17 August 2016

has use

agonist

2 references

7

17 August 2016

31

17 August 2016

1 reference

34

17 August 2016

1 reference

8

17 August 2016

1 reference

37

17 August 2016

1 reference

38

17 August 2016

1 reference

11

17 August 2016

1 reference

39

17 August 2016

1 reference

40

17 August 2016

1 reference

12

17 August 2016

1 reference

1

17 August 2016

1 reference

43

lysergic acid diethylamide

17 August 2016

has use

agonist

1 reference

17

17 August 2016

1 reference

19

17 August 2016

1 reference

20

17 August 2016

1 reference

44

17 August 2016

1 reference

45

17 August 2016

1 reference

3924

17 August 2016

1 reference

46

17 August 2016

1 reference

47

17 August 2016

1 reference

50

17 August 2016

1 reference

2

17 August 2016

1 reference

51

17 August 2016

1 reference

23

17 August 2016

1 reference

24

17 August 2016

1 reference

25

17 August 2016

1 reference

53

17 August 2016

1 reference

54

17 August 2016

1 reference

55

17 August 2016

1 reference

30

17 August 2016

1 reference

57

17 August 2016

1 reference

58

17 August 2016

1 reference

60

17 August 2016

1 reference

33

17 August 2016

1 reference

9

17 August 2016

1 reference

10

17 August 2016

1 reference

35

17 August 2016

1 reference

36

17 August 2016

1 reference

41

17 August 2016

1 reference

14

17 August 2016

1 reference

42

17 August 2016

1 reference

48

17 August 2016

1 reference

49

17 August 2016

1 reference

52

17 August 2016

2 references

26

17 August 2016

32

17 August 2016

1 reference

28

17 August 2016

1 reference

56

17 August 2016

1 reference

7427

17 August 2016

1 reference

7351

17 August 2016

1 reference

59

17 August 2016

1 reference

62

17 August 2016

1 reference

83

17 August 2016

1 reference

84

17 August 2016

1 reference

85

17 August 2016

1 reference

86

17 August 2016

1 reference

87

17 August 2016

1 reference

68

17 August 2016

1 reference

88

17 August 2016

1 reference

7227

17 August 2016

1 reference

89

17 August 2016

1 reference

73

17 August 2016

1 reference

90

17 August 2016

1 reference

91

17 August 2016

1 reference

92

17 August 2016

1 reference

93

17 August 2016

1 reference

94

17 August 2016

1 reference

95

17 August 2016

1 reference

96

17 August 2016

1 reference

97

17 August 2016

1 reference

72

17 August 2016

1 reference

98

17 August 2016

1 reference

99

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1 reference

100

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1 reference

101

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1 reference

79

17 August 2016

1 reference

80

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1 reference

102

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1 reference

103

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1512580

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL37744

aripiprazole lauroxil

object has role

Partial agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2219425

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL284092

buspirone hydrochloride

object has role

Partial agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200399

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08908

Commons category

5-HT1A serotonin receptor

0 references

topic's main category

Category:5-HT1A receptor

0 references

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

0 references

Guide to Pharmacology Target ID

1

1 reference

Wikimedia import URL

https://www.wikidata.org/w/index.php?title=Wikidata:Property_proposal/Guide_to_Pharmacology_Target_ID&oldid=709819452

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

Transporter Classification Database ID

9.A.14.3.14

2 references

Transporter Classification database

13 March 2020

Transporter Classification database