(Q21115613)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55085

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.13.12

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

G protein-coupled receptor activity

7 references

24 April 2018

Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085

24 April 2018

Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085

24 April 2018

Structural insight into allosteric modulation of protease-activated receptor 2.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085

signal transducer activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085

thrombin-activated receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 references

8 April 2019

Disulfide isomerization switches tissue factor from coagulation to cell signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Factor X/Xa Elicits Protective Signaling Responses in Endothelial Cells Directly via PAR-2 and Indirectly via Endothelial Protein C Receptor-dependent Recruitment of PAR-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Proteinase-activated receptors, nucleotide P2Y receptors, and μ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

signaling receptor binding

IPI

1 reference

8 April 2019

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

signaling receptor activity

TAS

1 reference

8 April 2019

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

G protein-coupled receptor activity

TAS

8 references

8 April 2019

Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Structural insight into allosteric modulation of protease-activated receptor 2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

1 reference

8 April 2019

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Structural insight into allosteric modulation of protease-activated receptor 2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

integral component of plasma membrane

1 reference

24 April 2018

Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085

1 reference

8 April 2019

ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

integral component of plasma membrane

positive regulation of Rho protein signal transduction

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085

24 April 2018

Factor X/Xa Elicits Protective Signaling Responses in Endothelial Cells Directly via PAR-2 and Indirectly via Endothelial Protein C Receptor-dependent Recruitment of PAR-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085

establishment of endothelial barrier

1 reference

8 April 2019

Factor X/Xa Elicits Protective Signaling Responses in Endothelial Cells Directly via PAR-2 and Indirectly via Endothelial Protein C Receptor-dependent Recruitment of PAR-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

thrombin-activated receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices

neutrophil activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of phagocytosis, engulfment

1 reference

8 April 2019

Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of toll-like receptor 3 signaling pathway

1 reference

8 April 2019

Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of eosinophil degranulation

1 reference

8 April 2019

Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of neutrophil mediated killing of gram-negative bacterium

1 reference

8 April 2019

Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

negative regulation of tumor necrosis factor-mediated signaling pathway

1 reference

8 April 2019

Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

immune system process

1 reference

8 April 2019

positive regulation of cytosolic calcium ion concentration

4 references

8 April 2019

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of JNK cascade

1 reference

8 April 2019

Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of leukocyte chemotaxis

1 reference

8 April 2019

TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

negative regulation of JNK cascade

1 reference

8 April 2019

Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

regulation of JNK cascade

1 reference

8 April 2019

Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

defense response to virus

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of ERK1 and ERK2 cascade

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of toll-like receptor 4 signaling pathway

1 reference

8 April 2019

Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of toll-like receptor 2 signaling pathway

1 reference

8 April 2019

Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of superoxide anion generation

1 reference

8 April 2019

Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

regulation of blood coagulation

1 reference

8 April 2019

Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

innate immune response

1 reference

8 April 2019

mature conventional dendritic cell differentiation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

negative regulation of toll-like receptor 3 signaling pathway

1 reference

8 April 2019

Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of actin filament depolymerization

1 reference

8 April 2019

Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

1 reference

8 April 2019

Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of positive chemotaxis

1 reference

8 April 2019

TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

G protein-coupled receptor signaling pathway

IBA

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Structural insight into allosteric modulation of protease-activated receptor 2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of GTPase activity

1 reference

8 April 2019

Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

cell-cell junction maintenance

1 reference

8 April 2019

Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

positive regulation of Rho protein signal transduction

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Factor X/Xa Elicits Protective Signaling Responses in Endothelial Cells Directly via PAR-2 and Indirectly via Endothelial Protein C Receptor-dependent Recruitment of PAR-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085

GPCR, rhodopsin-like, 7TM

IBA

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55085

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

Transporter Classification Database ID

9.A.14.13.12

2 references

Transporter Classification database

retrieved

13 March 2020