(Q21116339)

SAND-like domain superfamily

1 reference

Putative DNA-binding domain superfamily

1 reference

Ski-like, DNA-binding domain superfamily

1 reference

SKI/SNO/DAC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

c-SKI SMAD4-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

27 March 2018

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

transcription corepressor activity

1 reference

27 March 2018

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

protein domain specific binding

1 reference

27 March 2018

ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

RNA polymerase II cis-regulatory region sequence-specific DNA binding

IPI

1 reference

8 April 2019

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

DNA-binding transcription repressor activity, RNA polymerase II-specific

6 references

8 April 2019

Functional proteomics mapping of a human signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

8 April 2019

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

8 April 2019

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

8 April 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

4 references

27 March 2018

Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

DNA-binding transcription factor activity, RNA polymerase II-specific

protein-containing complex binding

ISM

NAS

1 reference

27 March 2018

ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

1 reference

27 March 2018

Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

Increased expression of c-Ski as a co-repressor in transforming growth factor-beta signaling correlates with progression of esophageal squamous cell carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

The expression of SnoN in normal human skin and cutaneous keratinous neoplasms

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

protein-containing complex

1 reference

8 April 2019

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

lymphocyte homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

Downregulation of Ski and SnoN co-repressors by anisomycin

response to antibiotic

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

negative regulation of transcription by RNA polymerase II

IEP

6 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

Sumoylated SnoN represses transcription in a promoter-specific manner

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

protein homotrimerization

1 reference

27 March 2018

Complex formation between proteins encoded by the ski gene family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

lens fiber cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

protein heterotrimerization

1 reference

27 March 2018

Complex formation between proteins encoded by the ski gene family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

response to growth factor

1 reference

27 March 2018

Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

skeletal muscle tissue development

1 reference

27 March 2018

Transforming growth factor-beta-independent regulation of myogenesis by SnoN sumoylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

negative regulation of BMP signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

transforming growth factor beta receptor signaling pathway

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

negative regulation of transforming growth factor beta receptor signaling pathway

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12757&geneProductId=UniProtKB:P12757

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

negative regulation of transforming growth factor beta receptor signaling pathway

IBA

IBA

positive regulation of axonogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12757

1 reference

c-SKI SMAD4-binding domain

1 reference