(Q24304249)

English

Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts

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scholarly article

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Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts (English)

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SKI proto-oncogene

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GOA release 2020-03-11

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GOA release 2020-03-11

author name string

Masatoshi Jinnin

1

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Hironobu Ihn

2

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Yoshihiro Mimura

3

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Yoshihide Asano

4

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Kunihiko Tamaki

5

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language of work or name

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publication date

May 2007

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Arthritis & Rheumatology

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56

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5

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1694-705

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Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

21 January 2018

IL-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase dependent pathway

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

21 January 2018

Phosphatidylinositol 3-kinase is involved in alpha2(I) collagen gene expression in normal and scleroderma fibroblasts

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

21 January 2018

Increased phosphorylation of transcription factor Sp1 in scleroderma fibroblasts: association with increased expression of the type I collagen gene

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor beta receptors

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Up-regulated expression of transforming growth factor beta receptors in dermal fibroblasts in skin sections from patients with localized scleroderma

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts. Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional activation of the alpha 1(I) procollagen gene in systemic sclerosis dermal fibroblasts. Role of intronic sequences

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Ski and SnoN: negative regulators of TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: insensitivity to TGF beta 1 stimulation

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

A Smad transcriptional corepressor

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Smads: transcriptional activators of TGF-beta responses

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Ski/Sno and TGF-beta signaling.

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a core functional and structural domain of the v-Ski oncoprotein responsible for both transformation and myogenesis.

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased Expression of TGF-β Receptors by Scleroderma Fibroblasts: Evidence for Contribution of Autocrine TGF-β Signaling to Scleroderma Phenotype

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional Regulation of the Human α2(I) Collagen Gene

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncostatin M Stimulates Transcription of the Human α2(I) Collagen Gene via the Sp1/Sp3-binding Site

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

c-myc is a downstream target of the Smad pathway

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

The Oncoprotein Ski Acts as an Antagonist of Transforming Growth Factor-β Signaling by Suppressing Smad2 Phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Transforming growth factor beta: the good, the bad, and the ugly

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of transforming growth factor-beta signaling in cancer

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation of human cDNA clones of ski and the ski-related gene, sno

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement of protein co-factor for the DNA-binding function of the human ski proto-oncogene product

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Proto-oncogene Sno expression, alternative isoforms and immediate early serum response

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutively phosphorylated Smad3 interacts with Sp1 and p300 in scleroderma fibroblasts

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunologic aspects of scleroderma

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Downregulation of Smad transcriptional corepressors SnoN and Ski in the fibrotic kidney: an amplification mechanism for TGF-beta1 signaling

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Altered regulation of collagen metabolism in scleroderma fibroblasts grown within three-dimensional collagen gels

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryos

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

The transforming growth factor-beta family

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts

1 reference

https://api.crossref.org/works/10.1002%2FART.22588

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/ART.22588

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