(Q14913250)

English

SKI proto-oncogene

mammalian protein found in Homo sapiens

v-ski avian sarcoma viral oncogene homolog
ski oncogene
SKI
proto-oncogene c-Ski
ski oncoprotein

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

SAND-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P12755

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P12755

Putative DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P12755

Ski-like, DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P12755

SKI/SNO/DAC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

c-SKI SMAD4-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transcription corepressor activity

determination method

protein domain specific binding

determination method

1 reference

8 April 2019

The Ski protein family is required for MeCP2-mediated transcriptional repression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

histone deacetylase inhibitor activity

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

zinc ion binding

determination method

1 reference

8 April 2019

Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

protein binding

determination method

17 references

8 April 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Complex formation between proteins encoded by the ski gene family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

The Ski-binding protein C184M negatively regulates tumor growth factor-beta signaling by sequestering the Smad proteins in the cytoplasm

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Functional proteomics mapping of a human signaling pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

DACH1 inhibits transforming growth factor-beta signaling through binding Smad4

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

determination method

3 references

27 March 2018

c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12755&geneProductId=UniProtKB:P12755

determination method

27 March 2018

Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12755&geneProductId=UniProtKB:P12755

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12755&geneProductId=UniProtKB:P12755

determination method

protein kinase binding

determination method

1 reference

8 April 2019

Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

determination method

4 references

8 April 2019

c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

determination method

1 reference

8 April 2019

Role of PML and PML-RARalpha in Mad-mediated transcriptional repression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

determination method

1 reference

8 April 2019

Identification of Ski as a target for Aurora A kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Nuclear and cytoplasmic c-Ski differently modulate cellular functions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

transcription regulator complex

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

transcription repressor complex

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

protein-containing complex

determination method

1 reference

8 April 2019

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

biological process

roof of mouth development

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

myotube differentiation

determination method

1 reference

8 April 2019

Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

SMAD protein signal transduction

determination method

1 reference

8 April 2019

Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

somatic stem cell population maintenance

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

nose morphogenesis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

determination method

1 reference

8 April 2019

SKI activates Wnt/beta-catenin signaling in human melanoma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

bone morphogenesis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

negative regulation of transcription by RNA polymerase II

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

negative regulation of transforming growth factor beta receptor signaling pathway

determination method

4 references

27 March 2018

SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12755&geneProductId=UniProtKB:P12755

determination method

27 March 2018

Nuclear and cytoplasmic c-Ski differently modulate cellular functions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12755&geneProductId=UniProtKB:P12755

determination method

27 March 2018

The protooncogene Ski controls Schwann cell proliferation and myelination

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12755&geneProductId=UniProtKB:P12755

determination method

27 March 2018

Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12755&geneProductId=UniProtKB:P12755

determination method

BMP signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

negative regulation of osteoblast differentiation

determination method

1 reference

8 April 2019

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

myelination in peripheral nervous system

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

protein homotrimerization

determination method

1 reference

8 April 2019

Complex formation between proteins encoded by the ski gene family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

negative regulation of BMP signaling pathway

determination method

positive regulation of Wnt signaling pathway

determination method

1 reference

8 April 2019

SKI activates Wnt/beta-catenin signaling in human melanoma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

negative regulation of activin receptor signaling pathway

determination method

1 reference

8 April 2019

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

neural tube closure

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

lens morphogenesis in camera-type eye

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

embryonic limb morphogenesis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

skeletal muscle fiber development

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

retina development in camera-type eye

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

camera-type eye development

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

positive regulation of DNA binding

determination method

1 reference

8 April 2019

c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

olfactory bulb development

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

cell population proliferation

determination method

1 reference

10 September 2018

SKI activates Wnt/beta-catenin signaling in human melanoma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12755&geneProductId=UniProtKB:P12755

determination method

anterior/posterior axis specification

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

negative regulation of fibroblast proliferation

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

face morphogenesis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

camera-type eye morphogenesis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

negative regulation of Schwann cell proliferation

determination method

1 reference

8 April 2019

The protooncogene Ski controls Schwann cell proliferation and myelination

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

negative regulation of cell population proliferation

determination method

1 reference

8 April 2019

Role of PML and PML-RARalpha in Mad-mediated transcriptional repression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

transcription, DNA-templated

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

negative regulation of histone deacetylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

neuron development

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

transforming growth factor beta receptor signaling pathway

determination method

1 reference

8 April 2019

SKI activates Wnt/beta-catenin signaling in human melanoma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

negative regulation of transforming growth factor beta receptor signaling pathway

determination method

5 references

8 April 2019

Nuclear and cytoplasmic c-Ski differently modulate cellular functions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

The protooncogene Ski controls Schwann cell proliferation and myelination

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

negative regulation of BMP signaling pathway

determination method

3 references

8 April 2019

Nuclear and cytoplasmic c-Ski differently modulate cellular functions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

negative regulation of cell differentiation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12755

determination method

Gene Atlas image

PBB GE SKI 204270 at fs.png
732 × 530; 12 KB

0 references

c-SKI SMAD4-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P12755

SKI/SNO/DAC domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P12755

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000367797

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367797

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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