(Q24310350)

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Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation

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scholarly article

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Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation (English)

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SMAD family member 3

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GOA release 2020-03-11

SMAD family member 1

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GOA release 2020-03-11

homeodomain interacting protein kinase 2

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GOA release 2020-03-11

SKI proto-oncogene

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GOA release 2020-03-11

SMAD protein signal transduction

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GOA release 2020-03-11

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based on heuristic

inferred from title

author name string

Jun Harada

1

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Kenji Kokura

2

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Chie Kanei-Ishii

3

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Teruaki Nomura

4

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Md Matiullah Khan

5

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Yongsok Kim

6

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Shunsuke Ishii

7

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language of work or name

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publication date

3 October 2003

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Journal of Biological Chemistry

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278

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38998-9005

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40

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NK-2 homeobox genes and heart development

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https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

The homeodomain-interacting kinase PKM (HIPK-2) modifies ND10 through both its kinase domain and a SUMO-1 interaction motif and alters the posttranslational modification of PML.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Histone deacetylase activity is required for full transcriptional repression by mSin3A

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

A Smad transcriptional corepressor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Smads as transcriptional co-modulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Signaling inputs converge on nuclear effectors in TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Human Smad3 and Smad4 are sequence-specific transcription activators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of PML and PML-RARalpha in Mad-mediated transcriptional repression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of activation of the TGF-beta receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

A transcriptional co-repressor that interacts with nuclear hormone receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Smad4 and FAST-1 in the assembly of activin-responsive factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

A human Mad protein acting as a BMP-regulated transcriptional activator

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

A transcriptional partner for MAD proteins in TGF-beta signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Viral ski inhibits retinoblastoma protein (Rb)-mediated transcriptional repression in a dominant negative fashion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of a bone morphogenetic protein-responsive Smad-binding element

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional control by the TGF-beta/Smad signaling system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation of human cDNA clones of ski and the ski-related gene, sno

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307112200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.M307112200

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