(Q21101042)

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

transcription coactivator activity

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2X6&geneProductId=UniProtKB:Q9H2X6

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2X6&geneProductId=UniProtKB:Q9H2X6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

1 reference

8 April 2019

Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

1 reference

8 April 2019

US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

2 references

10 references

8 April 2019

SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

HIPK2 associates with RanBPM

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

IPI

protein kinase activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

transcription corepressor activity

3 references

8 April 2019

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

protein serine/threonine kinase activity

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

5 references

8 April 2019

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

HIPK2 associates with RanBPM

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

anterior/posterior pattern specification

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

smoothened signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

How cells switch HIPK2 on and off

regulation of cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

positive regulation of DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

intrinsic apoptotic signaling pathway

1 reference

8 April 2019

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

transcription, DNA-templated

NAS

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2X6&geneProductId=UniProtKB:Q9H2X6

lens induction in camera-type eye

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

embryonic camera-type eye morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

1 reference

8 April 2019

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

positive regulation of transforming growth factor beta receptor signaling pathway

ISS

1 reference

8 April 2019

HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

1 reference

8 April 2019

Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

voluntary musculoskeletal movement

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

SMAD protein signal transduction

1 reference

8 April 2019

Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

adult walking behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

adult locomotory behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

protein phosphorylation

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

8 April 2019

The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

positive regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

cellular response to DNA damage stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

positive regulation of JNK cascade

1 reference

8 April 2019

HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

How cells switch HIPK2 on and off

PML body organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

negative regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

positive regulation of angiogenesis

1 reference

8 April 2019

Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

regulation of transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2X6&geneProductId=UniProtKB:Q9H2X6

embryonic retina morphogenesis in camera-type eye

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

modulation by virus of host process

1 reference

8 April 2019

US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

NAS

retina layer formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

cellular response to hypoxia

1 reference

8 April 2019

How cells switch HIPK2 on and off

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

positive regulation of protein phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

erythrocyte differentiation

1 reference

8 April 2019

Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

negative regulation of BMP signaling pathway

ISS

1 reference

8 April 2019

Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

regulation of signal transduction by p53 class mediator

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

transcription by RNA polymerase II

1 reference

27 February 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2X6&geneProductId=UniProtKB:Q9H2X6

negative regulation of ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2X6

serine/threonine-protein kinase, active site

has part(s)

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

inferred by common MeSH mappings on source and on Wikidata

Identifiers

MeSH descriptor ID

C115114

subject named as

HIPK2 protein, human

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference