(Q24310662)

cellular response to hypoxia

GOA release 2020-03-11

1 reference

Cell Death & Differentiation

GOA release 2020-03-11

author name string

D Sombroek

series ordinal

1

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T G Hofmann

series ordinal

2

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language of work or name

English

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publication date

February 2009

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published in

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volume

16

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page(s)

187-94

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issue

2

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cites work

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

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Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals

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Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival

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Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons

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Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

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US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest

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The function of PML in p53-dependent apoptosis

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Regulation of p53 activity in nuclear bodies by a specific PML isoform

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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

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Role of PML and the PML-nuclear body in the control of programmed cell death

20 April 2017

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Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression

20 April 2017

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p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

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Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1

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Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

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Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

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Signal transduction to hypoxia-inducible factor 1

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Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

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Cell cycle checkpoint signaling through the ATM and ATR kinases

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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TopBP1 activates the ATR-ATRIP complex

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Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

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Hyperactive Ras in developmental disorders and cancer

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Interfaces between the detection, signaling, and repair of DNA damage

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How cells activate ATR.

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

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Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

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Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.

21 January 2018

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Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.

21 January 2018

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A collective form of cell death requires homeodomain interacting protein kinase

21 January 2018

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Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.

21 January 2018

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HIPK2: a versatile switchboard regulating the transcription machinery and cell death

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HIPK2: a multitalented partner for transcription factors in DNA damage response and development.

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HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis

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The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues

21 January 2018

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Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription

21 January 2018

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Roles of HMGA proteins in cancer

21 January 2018

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High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.154

High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.

21 January 2018

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Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.154

High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.154

Homeodomain-interacting protein kinase-2 regulates apoptosis in developing sensory and sympathetic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

Body language: the function of PML nuclear bodies in apoptosis regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

c-Jun NH2-terminal kinase promotes apoptosis by down-regulating the transcriptional co-repressor CtBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

Apoptotic threshold is lowered by p53 transactivation of caspase-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

HIF hydroxylation and the mammalian oxygen-sensing pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

Ser46 phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanisms of regulation of p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

7 January 2021

PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

7 January 2021

Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

7 January 2021

Role of nuclear bodies in apoptosis signalling

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.154

7 January 2021