(Q37001370)

17 August 2017

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title

Roles of HMGA proteins in cancer (English)

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17 August 2017

Monica Fedele

2

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Alfredo Fusco

object named as

Alfredo Fusco

series ordinal

1

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language of work or name

English

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publication date

1 December 2007

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17 August 2017

Nature Reviews Cancer

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17 August 2017

7

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17 August 2017

12

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17 August 2017

899-910

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https://scigraph.springernature.com/pub.10.1038/nrc2271

17 August 2017

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cites work

Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y

1 reference

Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor

31 March 2020

1 reference

The high mobility group protein HMG I(Y) is required for NF-kappa B-dependent virus induction of the human IFN-beta gene

31 March 2020

1 reference

The high mobility group protein HMG I(Y) is an essential structural component of a virus-inducible enhancer complex

31 March 2020

1 reference

Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C

31 March 2020

1 reference

HMGI-C, a member of the high mobility group family of proteins, is expressed in hematopoietic stem cells and in leukemic cells

31 March 2020

1 reference

In vivo modulation of Hmgic reduces obesity

31 March 2020

1 reference

HMGA1 and HMGA2 protein expression in mouse spermatogenesis

31 March 2020

1 reference

Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes

31 March 2020

1 reference

Analysis of the HMGI nuclear proteins in mouse neoplastic cells induced by different procedures

31 March 2020

1 reference

On the presence of two new high mobility group‐like proteins in HeLa S3 cells

31 March 2020

1 reference

Inhibition of HMGI-C protein synthesis suppresses retrovirally induced neoplastic transformation of rat thyroid cells

31 March 2020

1 reference

Thyroid cell transformation requires the expression of the HMGA1 proteins

31 March 2020

1 reference

Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias

31 March 2020

1 reference

Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells

31 March 2020

1 reference

Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours

31 March 2020

1 reference

Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains

31 March 2020

1 reference

A specific translocation, t(12;14)(q14-15;q23-24), characterizes a subgroup of uterine leiomyomas

31 March 2020

1 reference

HMGIC expressed in a uterine leiomyoma with a deletion of the long arm of chromosome 7 along with a 12q14-15 rearrangement but not in tumors showing del(7) as the sole cytogenetic abnormality

31 March 2020

1 reference

A fibroadenoma with a t(4;12) (q27;q15) affecting the HMGI-C gene, a member of the high mobility group protein gene family

31 March 2020

1 reference

inv(12)(p11.2q13) in an endometrial polyp

31 March 2020

1 reference

Hidden paracentric inversions of chromosome arm 12q affecting the HMGIC gene

31 March 2020

1 reference

Regional fine mapping of the multiple-aberration region involved in uterine leiomyoma, lipoma, and pleomorphic adenoma of the salivary gland to 12q15

31 March 2020

1 reference

Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas

31 March 2020

1 reference

Molecular characterization of a complex chromosomal rearrangement in a pleomorphic salivary gland adenoma involving the 3'-UTR of HMGIC.

31 March 2020

1 reference

HMGA2 rearrangement in a case of vulvar aggressive angiomyxoma.

31 March 2020

1 reference

Amplification of a rearranged form of the high-mobility group protein gene HMGIC in OsA-CI osteosarcoma cells

31 March 2020

1 reference

Fusion of a sequence from HEI10 (14q11) to the HMGIC gene at 12q15 in a uterine leiomyoma.

31 March 2020

1 reference

LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family

31 March 2020

1 reference

A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas

31 March 2020

1 reference

Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts

31 March 2020

1 reference

The tumor suppressor microRNA let-7 represses the HMGA2 oncogene

31 March 2020

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Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation

31 March 2020

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High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma

31 March 2020

1 reference

A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomas

31 March 2020

1 reference

The expression of HMGA genes is regulated by their 3'UTR

31 March 2020

1 reference

Transgenic mice expressing a truncated form of the high mobility group I-C protein develop adiposity and an abnormally high prevalence of lipomas.

31 March 2020

1 reference

Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas

31 March 2020

1 reference

Misexpression of full-length HMGA2 induces benign mesenchymal tumors in mice

31 March 2020

1 reference

Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas

31 March 2020

1 reference

HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes

31 March 2020

1 reference

Expression of HMGIY in three uterine leiomyomata with complex rearrangements of chromosome 6

31 March 2020

1 reference

A high frequency of tumors with rearrangements of genes of the HMGI(Y) family in a series of 191 pulmonary chondroid hamartomas

31 March 2020

1 reference

Pleomorphic adenomas of the salivary glands: absence of HMGIY rearrangements

31 March 2020

1 reference

Significant correlation between the breakpoints of rare clonal aberrations in benign solid tumors and the assignment of HMGIY retropseudogenes

31 March 2020

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High-mobility group A2 gene expression is frequently induced in non-functioning pituitary adenomas (NFPAs), even in the absence of chromosome 12 polysomy

31 March 2020

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Cytogenetic study of pituitary adenomas

31 March 2020

1 reference

Non-random trisomies of chromosomes 5, 8 and 12 in the prolactinoma sub-type of pituitary adenomas: Conventional cytogenetics and interphase fish study

31 March 2020

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Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas.

31 March 2020

1 reference

Diagnostic significance of high mobility group I(Y) protein expression in intraductal papillary mucinous tumors of the pancreas

31 March 2020

1 reference

The expression of the high mobility group I(Y) mRNA in thyroid cancers: useful tool of differential diagnosis of thyroid nodules

31 March 2020

1 reference

High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases.

31 March 2020

1 reference

HMGI(Y) gene expression in colorectal cancer: comparison with some histological typing, grading, and clinical staging

31 March 2020

1 reference

HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression

31 March 2020

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Increased expression of high mobility group A proteins in lung cancer.

31 March 2020

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HMGA1 protein over-expression is a frequent feature of epithelial ovarian carcinomas

31 March 2020

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The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis.

31 March 2020

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Expression of HMGI(Y) associated with malignant phenotype of human gastric tissue.

31 March 2020

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High mobility group HMGI(Y) protein expression in head and neck squamous cell carcinoma

31 March 2020

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An increased high-mobility group A2 expression level is associated with malignant phenotype in pancreatic exocrine tissue

31 March 2020

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HMGA2 overexpression in non-small cell lung cancer.

31 March 2020

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Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity.

31 March 2020

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High mobility group I-C protein in astrocytoma and glioblastoma.

31 March 2020

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High mobility group A1 is expressed in metastatic adenocarcinoma to the liver and intrahepatic cholangiocarcinoma, but not in hepatocellular carcinoma: its potential use in the diagnosis of liver neoplasms.

31 March 2020

1 reference

Expression profiling in hepatocellular carcinoma with intrahepatic metastasis: identification of high-mobility group I(Y) protein as a molecular marker of hepatocellular carcinoma metastasis

31 March 2020

1 reference

Determination of high mobility group A1 (HMGA1) expression in hepatocellular carcinoma: a potential prognostic marker.

31 March 2020

1 reference

Transcriptional control of the human high mobility group A1 gene: basal and oncogenic Ras-regulated expression

31 March 2020

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High-mobility group A1 proteins are overexpressed in human leukaemias

31 March 2020

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A 12q13 translocation involving the HMGI-C gene in richter transformation of a chronic lymphocytic leukemia

31 March 2020

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Dysregulation and overexpression of HMGA2 in myelofibrosis with myeloid metaplasia

31 March 2020

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Cryptic 6p21.3 duplications and triplication involving HMGA1 partially masked by add 6p in four cases of myelodysplasia

31 March 2020

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Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies.

31 March 2020

1 reference

HMG-I/Y, a new c-Myc target gene and potential oncogene

31 March 2020

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Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway

31 March 2020

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The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia.

31 March 2020

1 reference

Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice.

31 March 2020

1 reference

A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation

31 March 2020

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Dual role for SUMO E2 conjugase Ubc9 in modulating the transforming and growth-promoting properties of the HMGA1b architectural transcription factor

31 March 2020

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Apoptosis and the cell cycle

31 March 2020

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Modulation of pRB/E2F functions in the regulation of cell cycle and in cancer.

31 March 2020

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HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity

31 March 2020

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Cyclin A is required at two points in the human cell cycle

31 March 2020

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Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2

31 March 2020

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AP-1 function and regulation

31 March 2020

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Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product

31 March 2020

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Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription

31 March 2020

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FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders

31 March 2020

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Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation

31 March 2020

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High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity.

31 March 2020

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HMGA1 inhibits the function of p53 family members in thyroid cancer cells.

31 March 2020

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High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.

31 March 2020

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Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases

31 March 2020

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Role of high mobility group (HMG) chromatin proteins in DNA repair.

31 March 2020

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High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity

31 March 2020

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Negative Regulation of BRCA1 Gene Expression by HMGA1 Proteins Accounts for the Reduced BRCA1 Protein Levels in Sporadic Breast Carcinoma

31 March 2020

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HMGA1 protein expression sensitizes cells to cisplatin-induced cell death

31 March 2020

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High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation

31 March 2020

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The cyclin A1-CDK2 complex regulates DNA double-strand break repair.

31 March 2020

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Inflammation by remote control

31 March 2020

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High mobility group-I(Y) protein facilitates nuclear factor-kappaB binding and transactivation of the inducible nitric-oxide synthase promoter/enhancer

31 March 2020

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Hypoxia induces high-mobility-group protein I(Y) and transcription of the cyclooxygenase-2 gene in human vascular endothelium

31 March 2020

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31 March 2020

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The non-histone chromosomal protein HMG-I(Y) contributes to repression of the immunoglobulin heavy chain germ-line epsilon RNA promoter

31 March 2020

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Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

31 March 2020

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High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters

31 March 2020

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The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements.

31 March 2020

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NF-kappaB mediated transcriptional activation is enhanced by the architectural factor HMGI-C.

31 March 2020

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A small region in HMG I(Y) is critical for cooperation with NF-kappaB on DNA.

31 March 2020

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Nitric oxide and the immune response

31 March 2020

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Molecular biology of nitric oxide synthases

31 March 2020

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Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

31 March 2020

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Molecular requirements for epithelial-mesenchymal transition during tumor progression

31 March 2020

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Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition.

31 March 2020

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MicroRNA deregulation in human thyroid papillary carcinomas.

31 March 2020

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A microRNA expression signature of human solid tumors defines cancer gene targets

31 March 2020

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Expression of high-mobility-group-protein HMGI-C mRNA in the peripheral blood is an independent poor prognostic indicator for survival in metastatic breast cancer

31 March 2020

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Therapy of human pancreatic carcinoma based on suppression of HMGA1 protein synthesis in preclinical models.

31 March 2020

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HMGA1 is a determinant of cellular invasiveness and in vivo metastatic potential in pancreatic adenocarcinoma

31 March 2020

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Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y)

31 March 2020

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Chromatin (dis)organization and cancer: BUR-binding proteins as biomarkers for cancer

31 March 2020

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Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice

31 March 2020

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC2271

1 reference

PubMed ID

18004397

Dimensions Publication ID

17 August 2017

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1 reference

PubMed ID

18004397