(Q40432782)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15843377%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified (English)

1 reference

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11 January 2020

0 references

0 references

5

1 reference

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11 January 2020

author name string

Lindsey D Mayo

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15843377%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Young Rok Seo

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15843377%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Mark W Jackson

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15843377%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Martin L Smith

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15843377%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Chandrashekhar K Korgaonkar

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15843377%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

David B Donner

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15843377%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

language of work or name

English

0 references

publication date

20 April 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15843377%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

11 January 2020

number of pages

7

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15843377%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

volume

280

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15843377%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

page(s)

25953-25959

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15843377%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

issue

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15843377%20AND%20SRC:MED&resulttype=core&format=json

p53, the cellular gatekeeper for growth and division

11 January 2020

cites work

1 reference

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

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p53 mutations in human cancers

21 January 2018

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Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1

21 January 2018

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The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

21 January 2018

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Functions of the MDM2 oncoprotein

21 January 2018

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

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Regulation of p53 stability by Mdm2

21 January 2018

1 reference

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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MDM2--master regulator of the p53 tumor suppressor protein

21 January 2018

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation

21 January 2018

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Mapping of the p53 and mdm-2 interaction domains

21 January 2018

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

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Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

21 January 2018

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The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

21 January 2018

1 reference

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

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PTEN and myotubularin: novel phosphoinositide phosphatases

21 January 2018

1 reference

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

21 January 2018

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Ten years of protein kinase B signalling: a hard Akt to follow

21 January 2018

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

1 reference

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Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503026200

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

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The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

21 January 2018

1 reference

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

1 reference

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

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Phosphorylation of HDM2 by Akt.

21 January 2018

1 reference

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PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy

21 January 2018

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Regulation of PTEN transcription by p53

21 January 2018

1 reference

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The importance of drug scheduling and recovery phases in determining drug activity. Improving etoposide efficacy in BCR-ABL-positive CML cells

21 January 2018

1 reference

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Differential regulation of phosphatidylserine externalization and DNA fragmentation by caspases in anticancer drug-induced apoptosis of rat mammary adenocarcinoma MTLn3 cells

21 January 2018

1 reference

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Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3.

21 January 2018

1 reference

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The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

21 January 2018

1 reference

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

21 January 2018

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

21 January 2018

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

21 January 2018

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Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

21 January 2018

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

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21 January 2018

Surfing the p53 network

1 reference

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The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

21 January 2018

1 reference

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Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.

21 January 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

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Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

21 January 2018

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PTEN: sometimes taking it off can be better than putting it on.

21 January 2018

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

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Targeting signal transduction pathways by chemopreventive agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503026200

Decision making by p53: life, death and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503026200

Multisite phosphorylation provides sophisticated regulation of transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503026200

Regulation of p53 responses by post-translational modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503026200