(Q40935748)

25 September 2017

Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis (English)

1 reference

25 September 2017

Sabbatini P

1

1 reference

PubMed ID

10446202

25 September 2017

McCormick F

series ordinal

2

1 reference

PubMed ID

10446202

25 September 2017

language of work or name

English

0 references

publication date

1 August 1999

1 reference

Journal of Biological Chemistry

25 September 2017

1 reference

25 September 2017

274

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25 September 2017

24263-24269

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25 September 2017

34

1 reference

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

25 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Phosphoinositide 3-kinases: a conserved family of signal transducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Signalling through the lipid products of phosphoinositide-3-OH kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Dimerization of cell surface receptors in signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Interleukin 3-dependent survival by the Akt protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Cancer. p53, guardian of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Cell cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Essential role for p53-mediated transcription in E1A-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

The polyproline region of p53 is required to activate apoptosis but not growth arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Bcl-2 blocks p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Cell death: the significance of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

21 January 2018

Bcl-2 family proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Lamin proteolysis facilitates nuclear events during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

21 January 2018

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Oncogene-dependent apoptosis is mediated by caspase-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

A genetic model for colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

ralGDS family members interact with the effector loop of ras p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Selective extraction of polyoma DNA from infected mouse cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Caspases: the proteases of the apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Role of p53 in apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

21 January 2018

Identifiers

DOI

10.1074/JBC.274.34.24263

1 reference

25 September 2017

1 reference

PubMed ID

10446202