(Q34761203)

4 August 2017

Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation (English)

1 reference

4 August 2017

Mark A McCoy

1

1 reference

4 August 2017

Jennifer J Gesell

series ordinal

2

1 reference

4 August 2017

Mary M Senior

series ordinal

3

1 reference

4 August 2017

Daniel F Wyss

series ordinal

4

1 reference

4 August 2017

language of work or name

English

0 references

publication date

27 January 2003

1 reference

Proceedings of the National Academy of Sciences of the United States of America

4 August 2017

1 reference

4 August 2017

100

1 reference

4 August 2017

1645-1648

1 reference

4 August 2017

4

1 reference

Mutation of mouse p53 Ser23 and the response to DNA damage

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Development of a binding assay for p53/HDM2 by using homogeneous time-resolved fluorescence.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Regulation of the p53 tumor suppressor protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Regulation of p53 function and stability by phosphorylation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Mdm2 association with p53 targets its ubiquitination

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Enhanced phosphorylation of p53 by ATM in response to DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Regulation of p53 stability by Mdm2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Mdm2 promotes the rapid degradation of p53

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

p53, the cellular gatekeeper for growth and division

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Discovering high-affinity ligands for proteins: SAR by NMR

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

The 13C chemical-shift index: a simple method for the identification of protein secondary structure using 13C chemical-shift data

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149886

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

7 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0334477100

Lipases reach the surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0334477100

Thermodynamics of p53 binding to hdm2(1-126): effects of phosphorylation and p53 peptide length

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0334477100

Comparative study of the p53-mdm2 and p53-MDMX interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0334477100

Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA-PK deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0334477100

Methodological advances in protein NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0334477100

Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12552135

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0334477100

1 reference

4 August 2017

0 references

1 reference

4 August 2017

1 reference