(Q40827743)

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ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation

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scholarly article

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Europe PubMed Central

24 September 2017

ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation (English)

1 reference

Europe PubMed Central

24 September 2017

phosphorylation

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author name string

S M de Toledo

1

1 reference

Europe PubMed Central

24 September 2017

E I Azzam

2

1 reference

Europe PubMed Central

24 September 2017

W K Dahlberg

3

1 reference

Europe PubMed Central

24 September 2017

T B Gooding

4

1 reference

Europe PubMed Central

24 September 2017

J B Little

5

1 reference

Europe PubMed Central

24 September 2017

language of work or name

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publication date

1 December 2000

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Europe PubMed Central

24 September 2017

1 reference

Europe PubMed Central

24 September 2017

19

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Europe PubMed Central

24 September 2017

6185-6193

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Europe PubMed Central

24 September 2017

54

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Europe PubMed Central

24 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1204020

0 references

Regulation of p53 stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Regulation of p53 function and stability by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Functions of the MDM2 oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

The complexity of p53 modulation: emerging patterns from divergent signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Nanotube Molecular Wires as Chemical Sensors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Three distinct signalling responses by murine fibroblasts to genotoxic stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Mechanisms of switching on p53: a role for covalent modification?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

ATM: a mediator of multiple responses to genotoxic stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

c-Abl neutralizes the inhibitory effect of Mdm2 on p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

MDM2 suppresses p73 function without promoting p73 degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Recombinant ATM protein complements the cellular A-T phenotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

21 January 2018

Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA-PK deficient cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

7 January 2021

based on heuristic

inferred from DOI database lookup

Use of semiquantitative reverse transcription-polymerase chain reaction to study gene expression in normal human skin fibroblasts following low dose-rate irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of confluent holding on potentially lethal damage repair, cell cycle progression, and chromosomal aberrations in human normal and ataxia-telangiectasia fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

7 January 2021

based on heuristic

inferred from DOI database lookup

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204020

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1204020

1 reference

Europe PubMed Central

24 September 2017

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1 reference

Europe PubMed Central

24 September 2017

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