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Regulation of p53 stability by Mdm2
scientific article (publication date: 15 May 1997)
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scholarly article
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title
Regulation of p53 stability by Mdm2
(English)
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author name string
M H Kubbutat
series ordinal
1
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S N Jones
series ordinal
2
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K H Vousden
series ordinal
3
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language of work or name
English
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publication date
15 May 1997
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published in
Nature
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volume
387
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page(s)
299-303
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issue
6630
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cites work
p53 in signaling checkpoint arrest or apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mapping of the p53 and mdm-2 interaction domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
mdm2 expression is induced by wild type p53 activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53-mdm-2 autoregulatory feedback loop
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction between the retinoblastoma protein and the oncoprotein MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of RB and p53 proteins in HPV-positive and HPV-negative cervical carcinoma cell lines.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 promotes the rapid degradation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 gene is induced in response to UV light in a p53-dependent manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F387299A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/387299A0
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
540666
Dimensions Publication ID
1037935695
0 references
Fatcat ID
release_hrfoi5uxpvantmahcc6arspsii
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/hrfoi5uxpvantmahcc6arspsii
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
OpenCitations bibliographic resource ID
540666
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
540666
PubMed ID
9153396
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
540666
ResearchGate publication ID
14065955
0 references
Springer Nature article ID
10.1038/387299a0
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