(Q34432885)

2 August 2017

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title

Ten years of protein kinase B signalling: a hard Akt to follow (English)

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2 August 2017

2

Hemmings BA

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2 August 2017

Brazil DP

1

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2 August 2017

1 November 2001

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2 August 2017

8

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Trends in Biochemical Sciences

inferred from page(s)

published in

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2 August 2017

26

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2 August 2017

657-664

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2 August 2017

11

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Cellular survival: a play in three Akts

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Thymic lymphoma induction by the AKT8 murine retrovirus

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Molecular cloning of a second form of rac protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Pleckstrin domain homology

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

A putative modular domain present in diverse signaling proteins

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https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

The Sequence of the Human Genome

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https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Structural characterization of the interaction between a pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

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https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Activation of phosphatidylinositol 3-kinase by insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Activation of p70/p85 S6 kinase by a pathway independent of p21ras

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Role of translocation in the activation and function of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

The multiple roles of PTEN in tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Pten is essential for embryonic development and tumour suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901958-2

7 January 2021

10.1016/S0968-0004(01)01958-2

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

11701324