(Q35334408)

English

Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes

scientific article

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scholarly article

1 reference

Europe PubMed Central

7 August 2017

Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes (English)

1 reference

Europe PubMed Central

7 August 2017

0 references

author name string

Thelen M

1

1 reference

Europe PubMed Central

7 August 2017

Wymann MP

2

1 reference

Europe PubMed Central

7 August 2017

Langen H

3

1 reference

Europe PubMed Central

7 August 2017

language of work or name

0 references

publication date

1 May 1994

1 reference

Europe PubMed Central

7 August 2017

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

7 August 2017

91

1 reference

Europe PubMed Central

7 August 2017

4960-4964

1 reference

Europe PubMed Central

7 August 2017

11

1 reference

Europe PubMed Central

7 August 2017

Neutrophil signal transduction and activation of the respiratory burst

1 reference

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12 July 2018

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

1 reference

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12 July 2018

Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase

1 reference

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12 July 2018

Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst

1 reference

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12 July 2018

Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins.

1 reference

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12 July 2018

Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells.

1 reference

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12 July 2018

Composition and organization of the NADPH oxidase of phagocytes and other cells

1 reference

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12 July 2018

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43909

12 July 2018

Structure and function of phosphatidylinositol 3-kinase: a potential second messenger system involved in growth control

1 reference

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12 July 2018

A biosensor approach to probe the structure and function of the p85 alpha subunit of the phosphatidylinositol 3-kinase complex

1 reference

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12 July 2018

Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit

1 reference

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Alkaline O leads to N-transacylation. A new method for the quantitative deacylation of phospholipids

1 reference

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Inhibition by calmodulin of calcium/phospholipid-dependent protein phosphorylation

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

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12 July 2018

An inositol tetrakisphosphate-containing phospholipid in activated neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43909

12 July 2018

The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43909

12 July 2018

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1 reference

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12 July 2018

Activation of monocytes by interferon-gamma has no effect on the level or affinity of the nicotinamide adenine dinucleotide-phosphate oxidase and on agonist-dependent superoxide formation

1 reference

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12 July 2018

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43909

12 July 2018

Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43909

12 July 2018

Purification and characterization of phosphoinositide 3-kinase from rat liver

1 reference

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12 July 2018

Reconstitution of cell-free NADPH-oxidase from human monocytes and comparison with neutrophils.

1 reference

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12 July 2018

Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane

1 reference

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12 July 2018

Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43909

12 July 2018

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43909

12 July 2018

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1 reference

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Molecular characterization of a mammalian smooth muscle myosin light chain kinase

1 reference

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Wortmannin, a microbial product inhibitor of myosin light chain kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43909

12 July 2018

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1 reference

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MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin

1 reference

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Subunits beta gamma of heterotrimeric G protein activate beta 2 isoform of phospholipase C

1 reference

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Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits

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Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

1 reference

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12 July 2018

Phosphatidylinositol-3 kinase and growth regulation

1 reference

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12 July 2018

Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase

1 reference

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12 July 2018

Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

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Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns

1 reference

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Activation of human neutrophil phospholipase D by three separable mechanisms

1 reference

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Signal transduction in neutrophil activation. Phosphatidylinositol 3-kinase is stimulated without tyrosine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8197165

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of inhibitors of distinct signalling pathways on neutrophil Q2- generation in response to tumor necrosis factor-alpha, and antibodies against CD18 and CD11a: evidence for a common and unique pattern of sensitivity to wortmannin and protein ty

1 reference

https://pubmed.ncbi.nlm.nih.gov/8197165

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of tyrosine phosphorylation by wortmannin in human neutrophils. Dissociation from its inhibitory effects on phospholipase D

1 reference

https://pubmed.ncbi.nlm.nih.gov/8197165

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/8197165

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based on heuristic

inferred from PubMed ID database lookup

Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/8197165

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based on heuristic

inferred from PubMed ID database lookup

Two transduction sequences are necessary for neutrophil activation by receptor agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/8197165

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.91.11.4960

1 reference

Europe PubMed Central

7 August 2017

1994PNAS...91.4960T

0 references

1 reference

Europe PubMed Central

7 August 2017

1 reference

Europe PubMed Central

7 August 2017

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