(Q24338503)

intrinsic apoptotic signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Gabriella D'Orazi

5

0 references

Ada Sacchi

3

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Silvia Soddu

4

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author name string

Valeria Di Stefano

1

0 references

Giovanni Blandino

Post-translational modifications and activation of p53 by genotoxic stresses

2

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language of work or name

English

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publication date

1 July 2004

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published in

Oncogene

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volume

23

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issue

30

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page(s)

5185-92

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cites work

1 reference

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

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Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

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Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

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Mdm2 overexpression and p14(ARF) inactivation are two mutually exclusive events in primary human lung tumors

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

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The complexity of p53 modulation: emerging patterns from divergent signals

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Mdm2 promotes the rapid degradation of p53

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo

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Regulation of p53 stability by Mdm2

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Regulation of p53 in response to DNA damage

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Abnormal expression of MDM2 in prostate carcinoma.

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Human TAFII31 protein is a transcriptional coactivator of the p53 protein

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

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Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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Amplification of a gene encoding a p53-associated protein in human sarcomas

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The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?

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A model for p53-induced apoptosis

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

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Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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DNA damage induces phosphorylation of the amino terminus of p53

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Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

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The cellular response to p53: the decision between life and death

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HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels

21 January 2018

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The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

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mdm2 expression is induced by wild type p53 activity

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Stress-activated kinases regulate protein stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207656

inferred from DOI database lookup

7 January 2021

based on heuristic

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207656