(Q21116808)

http://www.ebi.ac.uk/interpro/protein/P18850

Basic-leucine zipper domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

8 April 2019

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

DNA-binding transcription factor activity

4 references

8 April 2019

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

Interaction of ATF6 and serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

transcription coactivator activity

1 reference

8 April 2019

ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

transcription cis-regulatory region binding

TAS

1 reference

8 April 2019

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

5 references

8 April 2019

A thrombospondin-dependent pathway for a protective ER stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

protein heterodimerization activity

IPI

1 reference

8 April 2019

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

ubiquitin protein ligase binding

IPI

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

cAMP response element binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

sequence-specific DNA binding

1 reference

8 April 2019

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

integral component of membrane

ISA

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

1 reference

8 April 2019

CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

1 reference

8 April 2019

ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

integral component of endoplasmic reticulum membrane

TAS

2 references

8 April 2019

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

endoplasmic reticulum

3 references

8 April 2019

8 April 2019

CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

7 references

8 April 2019

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

1 reference

8 April 2019

Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

regulation of transcription, DNA-templated

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

4 references

27 March 2018

The unfolded protein response: integrating stress signals through the stress sensor IRE1α

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850

27 March 2018

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850

27 March 2018

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850

27 March 2018

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850

regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

transcription, DNA-templated

TAS

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850

response to unfolded protein

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

1 reference

8 April 2019

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

1 reference

8 April 2019

Interaction of ATF6 and serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

1 reference

8 April 2019

Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

positive regulation of apoptotic process

IMP

1 reference

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

transcription by RNA polymerase II

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850

positive regulation of transcription by RNA polymerase II

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

positive regulation of ATF6-mediated unfolded protein response

1 reference

8 April 2019

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

3 references

8 April 2019

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

8 April 2019

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

Basic-leucine zipper domain

has part(s)

1 reference

stated in

InterPro Release 71.0