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(Q21118772)
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methylmalonate-semialdehyde dehydrogenase (acylating) activity
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
GO:0004491
MSDH activity
2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
MMSA dehydrogenase activity
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Statements
instance of
molecular function
1 reference
stated in
Gene Ontology release 2019-10-07
retrieved
12 October 2019
Gene Ontology ID
GO:0004491
subclass of
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
1 reference
stated in
Gene Ontology release 2019-10-07
retrieved
12 October 2019
Gene Ontology ID
GO:0004491
EC enzyme number
1.2.1.27
1 reference
stated in
Gene Ontology release 2019-10-07
retrieved
11 October 2019
Gene Ontology ID
GO:0004491
exact match
http://purl.obolibrary.org/obo/GO_0004491
1 reference
stated in
Gene Ontology release 2019-10-07
retrieved
11 October 2019
Gene Ontology ID
GO:0004491
https://www.rhea-db.org/rhea/20804
1 reference
reference URL
http://geneontology.org/external2go/rhea2go
has part(s)
NAD(1−)
part of
left side of reaction
1 reference
stated in
Gene Ontology release 2020-05-02
Rhea release 113
2-methyl-3-oxopropanoate
part of
left side of reaction
1 reference
stated in
Gene Ontology release 2020-05-02
Rhea release 113
water
part of
left side of reaction
1 reference
stated in
Gene Ontology release 2020-05-02
Rhea release 113
coenzyme A(4-)
part of
left side of reaction
1 reference
stated in
Gene Ontology release 2020-05-02
Rhea release 113
NADH(2-)
part of
right side of reaction
1 reference
stated in
Gene Ontology release 2020-05-02
Rhea release 113
hydron
part of
right side of reaction
1 reference
stated in
Gene Ontology release 2020-05-02
Rhea release 113
bicarbonate ion
part of
right side of reaction
1 reference
stated in
Gene Ontology release 2020-05-02
Rhea release 113
propionyl-CoA(4-)
part of
right side of reaction
1 reference
stated in
Gene Ontology release 2020-05-02
Rhea release 113
Identifiers
Gene Ontology ID
GO:0004491
1 reference
stated in
Gene Ontology release 2019-10-07
retrieved
11 October 2019
Gene Ontology ID
GO:0004491
UMLS CUI
C1151669
1 reference
based on heuristic
inferred by common GO mappings on source and on Wikidata
stated in
UMLS 2023
retrieved
15 June 2023
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