(Q21118811)

Metallothionein, vertebrate

1 reference

Metallothionein domain superfamily

1 reference

Metallothionein, vertebrate, metal binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Effect of alpha-domain substitution on the structure, property and function of human neuronal growth inhibitory factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Redox activity of α-synuclein-Cu is silenced by Zn₇-metallothionein-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Reaction of human metallothionein-3 with cisplatin and transplatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

protein kinase activator activity

1 reference

8 April 2019

Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

1 reference

8 April 2019

The unique N-terminal sequence of metallothionein-3 is required to regulate the choice between apoptotic or necrotic cell death of human proximal tubule cells exposed to Cd+2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

Protective effect of metallothionein-III on DNA damage in response to reactive oxygen species

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

3 references

8 April 2019

Redox activity of α-synuclein-Cu is silenced by Zn₇-metallothionein-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

3 references

8 April 2019

The functional significance of brain metallothioneins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Redox activity of α-synuclein-Cu is silenced by Zn₇-metallothionein-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

3 references

8 April 2019

Effect of alpha-domain substitution on the structure, property and function of human neuronal growth inhibitory factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

The effect of nitric oxide on metal release from metallothionein-3: gradual unfolding of the protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

The role of Thr5 in human neuron growth inhibitory factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

27 March 2018

Expression of MT-3 protein in the human kidney

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25713&geneProductId=UniProtKB:P25713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

rough endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

intracellular anatomical structure

1 reference

10 September 2018

Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25713&geneProductId=UniProtKB:P25713

mitochondrial outer membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

Association of metallothionein-III with oligodendroglial cytoplasmic inclusions in multiple system atrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

perinuclear region of cytoplasm

1 reference

8 April 2019

Association of metallothionein-III with oligodendroglial cytoplasmic inclusions in multiple system atrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

positive regulation of necrotic cell death

biological process

2 references

8 April 2019

Expression of metallothionein isoform 3 (MT-3) determines the choice between apoptotic or necrotic cell death in Cd+2-exposed human proximal tubule cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

The unique N-terminal sequence of metallothionein-3 is required to regulate the choice between apoptotic or necrotic cell death of human proximal tubule cells exposed to Cd+2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

positive regulation of vascular endothelial growth factor receptor signaling pathway

1 reference

8 April 2019

Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

activation of protein kinase B activity

1 reference

8 April 2019

Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

The unique N-terminal sequence of metallothionein-3 is required to regulate the choice between apoptotic or necrotic cell death of human proximal tubule cells exposed to Cd+2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

positive regulation of protein phosphorylation

1 reference

8 April 2019

Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

positive regulation of cell death

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

The unique N-terminal sequence of metallothionein-3 is required to regulate the choice between apoptotic or necrotic cell death of human proximal tubule cells exposed to Cd+2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

Expression of metallothionein-III induced by hypoxia attenuates hypoxia-induced cell death in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

The effect of nitric oxide on metal release from metallothionein-3: gradual unfolding of the protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

protein kinase B signaling

1 reference

8 April 2019

Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

removal of superoxide radicals

IMP

1 reference

8 April 2019

Protective effect of metallothionein-III on DNA damage in response to reactive oxygen species

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner

ERK1 and ERK2 cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

negative regulation of neurogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells

protein stabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

response to metal ion

1 reference

8 April 2019

negative regulation of apoptotic process

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Expression of metallothionein isoform 3 (MT-3) determines the choice between apoptotic or necrotic cell death in Cd+2-exposed human proximal tubule cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

cellular response to cadmium ion

1 reference

27 March 2018

The unique N-terminal sequence of metallothionein-3 is required to regulate the choice between apoptotic or necrotic cell death of human proximal tubule cells exposed to Cd+2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25713&geneProductId=UniProtKB:P25713

cellular metal ion homeostasis

3 references

8 April 2019

Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Protective effect of metallothionein-III on DNA damage in response to reactive oxygen species

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

response to oxidative stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

negative regulation of hydrogen peroxide catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

negative regulation of cysteine-type endopeptidase activity

1 reference

8 April 2019

Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

positive regulation of transcription, DNA-templated

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

positive regulation of gene expression

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

negative regulation of cell growth

4 references

8 April 2019

The effect of nitric oxide on metal release from metallothionein-3: gradual unfolding of the protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Mutation at Glu23 eliminates the neuron growth inhibitory activity of human metallothionein-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Effect of alpha-domain substitution on the structure, property and function of human neuronal growth inhibitory factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

The role of Thr5 in human neuron growth inhibitory factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress

1 reference

8 April 2019

Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

negative regulation of oxidoreductase activity

1 reference

8 April 2019

Redox activity of α-synuclein-Cu is silenced by Zn₇-metallothionein-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

positive regulation of ERK1 and ERK2 cascade

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25713&geneProductId=UniProtKB:P25713

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25713&geneProductId=UniProtKB:P25713

27 March 2018

Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25713&geneProductId=UniProtKB:P25713

cellular response to nitric oxide

1 reference

8 April 2019

The effect of nitric oxide on metal release from metallothionein-3: gradual unfolding of the protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

negative regulation of reactive oxygen species metabolic process

1 reference

8 April 2019

Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

cell population proliferation

1 reference

1 January 2018

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

negative regulation of necrotic cell death

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

cellular response to hypoxia

1 reference

8 April 2019

PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

negative regulation of neuron death

IEP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

cellular zinc ion homeostasis

3 references

detoxification of copper ion

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

positive regulation of ERK1 and ERK2 cascade

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

cellular response to cadmium ion

cellular response to copper ion

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

cellular response to zinc ion

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

negative regulation of neuron projection development

1 reference

8 April 2019

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713

Metallothionein, vertebrate, metal binding site

has part(s)

1 reference

inferred by common MeSH mappings on source and on Wikidata

Identifiers

MeSH descriptor ID

D000090023

subject named as

Metallothionein 3

0 references

0 references

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

1 reference