(Q21120665)

English

Iodothyronine deiodinase 2

mammalian protein found in Homo sapiens

DIOII
type-II 5'-deiodinase
deiodinase, iodothyronine type II
type 2 DI
5DII
deiodinase-2
type-II 5'deiodinase
type 2 iodothyronine deiodinase
thyroxine deiodinase, type II
DIO2
deiodonase-2
type II iodothyronine deiodinase

In more languages

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Statements

1 reference

13 November 2019

Thioredoxin-like superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q92813

Iodothyronine deiodinase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q92813

Iodothyronine deiodinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

oxidoreductase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

thyroxine 5'-deiodinase activity

4 references

27 March 2018

The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92813&geneProductId=UniProtKB:Q92813

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92813&geneProductId=UniProtKB:Q92813

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92813&geneProductId=UniProtKB:Q92813

27 March 2018

The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92813&geneProductId=UniProtKB:Q92813

determination method

IDA

ubiquitin protein ligase binding

1 reference

8 April 2019

The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

determination method

IPI

thyroxine 5'-deiodinase activity

4 references

8 April 2019

The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

8 April 2019

The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

determination method

IBA

cell component

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

determination method

TAS

biological process

thyroid hormone metabolic process

1 reference

27 March 2018

The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92813&geneProductId=UniProtKB:Q92813

determination method

IDA

thyroid hormone generation

3 references

8 April 2019

The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

8 April 2019

Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

determination method

TAS

selenocysteine incorporation

1 reference

8 April 2019

The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

determination method

NAS

hormone biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

determination method

IEA

positive regulation of cold-induced thermogenesis

1 reference

8 April 2019

The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92813

determination method

ISS

has part(s)

Iodothyronine deiodinase, active site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q92813

Identifiers

MeSH descriptor ID

D000097564

subject named as

Iodothyronine Deiodinase Type II

0 references

MeSH tree code

D08.811.682.732.525.500

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

(Q21120665)

Iodothyronine deiodinase 2

Statements

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