Wikidata

(Q21121619)

English

Nuclear factor of activated T cells 2

mammalian protein found in Homo sapiens

  • T cell transcription factor NFAT1
  • NF-ATp
  • NFATC2
  • T-cell transcription factor NFAT1
  • preexisting nuclear factor of activated T-cells 2
  • NFAT pre-existing subunit
  • NF-ATc2
  • nuclear factor of activated T-cells, preexisting component
  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
  • NFAT transcription complex, preexisting component
  • nuclear factor of activated T-cells, cytoplasmic 2
In more languages

Statements

molecular function
protein binding
determination method
IPI
10 references
retrieved
8 April 2019
stated in
Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2
GOA
curator
UniProt
UniProt protein ID
Q13469
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IPI
retrieved
8 April 2019
stated in
FOXP3 controls regulatory T cell function through cooperation with NFAT
GOA
curator
UniProt
UniProt protein ID
Q13469
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IPI
retrieved
8 April 2019
stated in
Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells
GOA
curator
UniProt
UniProt protein ID
Q13469
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IPI
retrieved
8 April 2019
stated in
NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins
GOA
curator
UniProt
UniProt protein ID
Q13469
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IPI
retrieved
8 April 2019
stated in
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
GOA
curator
UniProt
UniProt protein ID
Q13469
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IPI
retrieved
8 April 2019
stated in
Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IPI
retrieved
8 April 2019
stated in
The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IPI
retrieved
8 April 2019
stated in
USP22 is a positive regulator of NFATc2 on promoting IL2 expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IPI
retrieved
8 April 2019
stated in
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IPI
cell component
nucleus
determination method
IDA
TAS
IEA
5 references
retrieved
24 April 2018
stated in
Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes
GOA
curator
UniProt
UniProt protein ID
Q13469
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469
determination method
TAS
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q13469
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469
determination method
IEA
retrieved
24 April 2018
stated in
Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes
GOA
curator
UniProt
UniProt protein ID
Q13469
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469
determination method
IDA
retrieved
24 April 2018
stated in
Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
TAS
6 references
retrieved
8 April 2019
stated in
Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes
GOA
curator
UniProt
UniProt protein ID
Q13469
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13469
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IEA
retrieved
8 April 2019
stated in
Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes
GOA
curator
UniProt
UniProt protein ID
Q13469
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IDA
retrieved
8 April 2019
stated in
Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469
determination method
IBA
biological process

Identifiers

 
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