(Q21123501)

English

Tau tubulin kinase 1

mammalian protein found in Homo sapiens

brain-derived tau kinase
TTBK1
tau-tubulin kinase 1

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5TCY1

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

protein kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

determination method

2 references

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

protein serine/threonine kinase activity

determination method

3 references

8 April 2019

Roles of tau protein in health and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

tau protein binding

determination method

1 reference

8 April 2019

Roles of tau protein in health and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

tau-protein kinase activity

determination method

1 reference

8 April 2019

Roles of tau protein in health and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

microtubule associated complex

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

biological process

protein phosphorylation

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5TCY1&geneProductId=UniProtKB:Q5TCY1

determination method

peptidyl-serine phosphorylation

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5TCY1&geneProductId=UniProtKB:Q5TCY1

determination method

substantia nigra development

determination method

1 reference

26 September 2017

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5TCY1&geneProductId=UniProtKB:Q5TCY1

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

regulation of cell shape

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5TCY1&geneProductId=UniProtKB:Q5TCY1

determination method

learning or memory

determination method

1 reference

8 April 2019

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

negative regulation of gene expression

determination method

1 reference

8 April 2019

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

substantia nigra development

determination method

1 reference

8 April 2019

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

negative regulation of protein binding

determination method

1 reference

8 April 2019

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

positive regulation of protein polymerization

determination method

1 reference

8 April 2019

Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

positive regulation of astrocyte activation

determination method

1 reference

8 April 2019

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

positive regulation of microglial cell activation

determination method

1 reference

8 April 2019

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

positive regulation of cyclin-dependent protein kinase activity

determination method

1 reference

8 April 2019

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

positive regulation of cysteine-type endopeptidase activity

determination method

1 reference

8 April 2019

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5TCY1

determination method

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5TCY1

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5TCY1

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000259750

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000259750

ENSP00000307357

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000307357

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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