(Q34913399)

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Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

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scholarly article

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Europe PubMed Central

PubMed publication ID

5 August 2017

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Tau tubulin kinase 1

1 reference

GOA release 2020-03-11

positive regulation of cysteine-type endopeptidase activity

1 reference

GOA release 2020-03-11

Cyclin-dependent kinase 5

1 reference

GOA release 2020-03-11

Glutamate receptor, ionotropic, NMDA2B (epsilon 2)

1 reference

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Cyclin-dependent kinase 5, regulatory subunit 1 (p35)

1 reference

GOA release 2020-03-11

10

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

Pawel Ciborowski

9

object named as

Pawel Ciborowski

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

author name string

Shinji Sato

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

Jiqing Xu

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

Satoshi Okuyama

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

Lindsey B Martinez

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

Shannon M Walsh

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

Michael T Jacobsen

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

Russell J Swan

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

Joshua D Schlautman

8

1 reference

Europe PubMed Central

PMC publication ID

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16 May 2020

language of work or name

0 references

publication date

1 December 2008

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

28

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

53

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

14511-14521

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurobiology: p25 protein in neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term culture of mouse cortical neurons as a model for neuronal development, aging, and death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase complement of the human genome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of mitogen-activated protein kinase pathways in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of cDK5/p35 by oxidative stress in human neuroblastoma IMR-32 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and evaluation of fluorescent probes for the detection of calpain activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADENOSINE TRIPHOSPHATE CLEAVAGE DURING THE G-ACTIN TO F-ACTIN TRANSFORMATION AND THE BINDING OF ADENOSINE DIPHOSPHATE TO F-ACTIN

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective activation induced cleavage of the NR2B subunit by calpain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase 5 in neurofilament function and regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid deposition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of N-methyl-D-aspartate receptors by calpain in cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sexual dimorphisms in the effect of low-level p25 expression on synaptic plasticity and memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is there a role of the cyclin-dependent kinase 5 activator p25 in Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glomerular podocytes contain neuron-like functional synaptic vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase-3 inhibition is integral to long-term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CpG island mapping by epigenome prediction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurabin-I is phosphorylated by Cdk5: implications for neuronal morphogenesis and cortical migration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal Fluid Proteomic Profiling of HIV-1-Infected Patients with Cognitive Impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protein kinase II is involved in the regulation of the normal phosphorylation state of tau protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiology and pathology of tau protein kinases in relation to Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3beta transgenes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of microtubule-associated protein tau on Ser 262 by an embryonic 100 kDa protein kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia-specific localisation of a novel calcium binding protein, Iba1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19118186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3417-08.2008

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671237&resulttype=core&format=json

16 May 2020

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