(Q28145382)

2

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M Li

3

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J Peng

4

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R M Friedlander

5

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L H Tsai

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

6

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language of work or name

English

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publication date

18 May 2000

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published in

Nature

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volume

405

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issue

6784

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page(s)

360-4

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cites work

1 reference

7 January 2021

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

1 reference

7 January 2021

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

1 reference

7 January 2021

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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7 January 2021

Structure and physiological function of calpains

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7 January 2021

A brain-specific activator of cyclin-dependent kinase 5.

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7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

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7 January 2021

Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death

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7 January 2021

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes

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7 January 2021

beta-Amyloid protein amplifies calcium signalling in central neurons from the adult mouse.

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7 January 2021

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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7 January 2021

Calcium alterations in Alzheimer's disease: pathophysiology, models and therapeutic opportunities

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7 January 2021

Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease.

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7 January 2021

Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease

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7 January 2021

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

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7 January 2021

Localization of calpain immunoreactivity in senile plaques and in neurones undergoing neurofibrillary degeneration in Alzheimer's disease

1 reference

7 January 2021

Translating cell biology into therapeutic advances in Alzheimer's disease

1 reference

7 January 2021

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1 reference

7 January 2021