(Q21126786)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99572

P2X7 purinoceptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99572

P2X purinoreceptor

1 reference

Transporter Classification Database ID

1.A.7.1.3

hierarchical database ID heuristic

2 October 2019

based on heuristic

1 reference

13 November 2019

1 reference

13 November 2019

signaling receptor binding

1 reference

24 April 2018

Evidence for functional P2X4/P2X7 heteromeric receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

protein homodimerization activity

IC

1 reference

24 April 2018

Go it alone no more--P2X7 joins the society of heteromeric ATP-gated receptor channels

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

extracellularly ATP-gated cation channel activity

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

signaling receptor activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

Evidence for functional P2X4/P2X7 heteromeric receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

integral component of membrane

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

neuromuscular junction

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

Evidence for functional P2X4/P2X7 heteromeric receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

integral component of nuclear inner membrane

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

integral component of plasma membrane

IBA

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

external side of plasma membrane

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

cellular response to extracellular stimulus

biological process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of protein phosphorylation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of calcium ion transport into cytosol

1 reference

24 April 2018

The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

regulation of sodium ion transport

1 reference

24 April 2018

Evidence for functional P2X4/P2X7 heteromeric receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of catalytic activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

response to organic substance

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

phospholipid transfer to membrane

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of cytolysis

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

protein phosphorylation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

cell surface receptor signaling pathway

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

membrane protein ectodomain proteolysis

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

phospholipid translocation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of interleukin-1 beta production

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

apoptotic signaling pathway

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of gamma-aminobutyric acid secretion

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

calcium ion transport

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

defense response to Gram-positive bacterium

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

extrinsic apoptotic signaling pathway

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

synaptic vesicle exocytosis

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

ceramide biosynthetic process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

response to mechanical stimulus

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

reactive oxygen species metabolic process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

phagolysosome assembly

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

regulation of killing of cells of other organism

1 reference

24 April 2018

Evidence for functional P2X4/P2X7 heteromeric receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of prostaglandin secretion

NAS

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of interleukin-6 production

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

inflammatory response

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

plasma membrane organization

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of ion transmembrane transport

1 reference

24 April 2018

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of MAPK cascade

IMP

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

release of sequestered calcium ion into cytosol

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

cell volume homeostasis

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

plasma membrane phospholipid scrambling

1 reference

24 April 2018

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of lymphocyte apoptotic process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

skeletal system morphogenesis

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

cellular response to organic cyclic compound

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA

membrane depolarization

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

mitochondrion organization

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of T cell mediated cytotoxicity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

collagen metabolic process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

pore complex assembly

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

response to electrical stimulus

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of ossification

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

cation transmembrane transport

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

response to fluid shear stress

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

response to calcium ion

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

response to lipopolysaccharide

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of mitochondrial depolarization

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

vesicle budding from membrane

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of protein secretion

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

homeostasis of number of cells within a tissue

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of bleb assembly

1 reference

24 April 2018

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

24 April 2018

The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

response to bacterium

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

response to organic cyclic compound

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

programmed cell death

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

cellular response to dsRNA

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of gene expression

1 reference

24 April 2018

The P2X7 receptor is a key modulator of aerobic glycolysis

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

protein complex oligomerization

IMP

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of glutamate secretion

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of cytoskeleton organization

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of apoptotic process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

positive regulation of glycolytic process

1 reference

24 April 2018

The P2X7 receptor is a key modulator of aerobic glycolysis

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

purinergic nucleotide receptor signaling pathway

IMP

1 reference

24 April 2018

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

excitatory postsynaptic potential

TAS

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

protein catabolic process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99572&geneProductId=UniProtKB:Q99572

physically interacts with

adenosine triphosphate

has use

agonist

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

1713

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5953

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4235

language of work or name

17 August 2016

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3545108

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1823817

exact match

http://purl.uniprot.org/uniprot/Q99572

1 reference

Transporter Classification Database ID

Identifiers.org

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1.A.7.1.3

2 references

Transporter Classification database

13 March 2020

Transporter Classification database