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Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages
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scholarly article
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title
Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages
(English)
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main subject
macrophage
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negative regulation of bleb assembly
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:1904171
positive regulation of bleb assembly
2 references
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:1904172
stated in
GOA release 2020-03-11
regulation of bleb assembly
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:1904170
Purinergic receptor P2X 7
1 reference
stated in
GOA release 2020-03-11
Anoctamin 6
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stated in
GOA release 2020-03-11
Chemokine (C-C motif) ligand 2
1 reference
stated in
GOA release 2020-03-11
Anoctamin 6
1 reference
stated in
GOA release 2020-03-11
Purinergic receptor P2X, ligand-gated ion channel, 7
1 reference
stated in
GOA release 2020-03-11
author
Karl Kunzelmann
series ordinal
7
object named as
Karl Kunzelmann
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author name string
Jiraporn Ousingsawat
series ordinal
1
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Podchanart Wanitchakool
series ordinal
2
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Arthur Kmit
series ordinal
3
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Ana M Romao
series ordinal
4
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Walailak Jantarajit
series ordinal
5
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Rainer Schreiber
series ordinal
6
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language of work or name
English
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publication date
2015
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published in
Nature Communications
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volume
6
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page(s)
6245
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cites work
The human P2X7 receptor and its role in innate immunity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
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inferred from DOI database lookup
Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
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inferred from DOI database lookup
P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteomic and functional evidence for a P2X7 receptor signalling complex
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation and regulation of purinergic P2X receptor channels
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATP-induced P2X7-associated uptake of large molecules involves distinct mechanisms for cations and anions in macrophages.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
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7 January 2021
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inferred from DOI database lookup
P2X7 receptor activates multiple selective dye-permeation pathways in RAW 264.7 and human embryonic kidney 293 cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
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7 January 2021
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Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
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7 January 2021
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Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Point mutations confer loss of ATP-induced human P2X(7) receptor function
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Experimental characterization and mathematical modeling of P2X7 receptor channel gating.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
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7 January 2021
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inferred from DOI database lookup
Calcium-dependent phospholipid scrambling by TMEM16F
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
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7 January 2021
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inferred from DOI database lookup
Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anoctamins are a family of Ca2+-activated Cl- channels
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TMEM16F (Anoctamin 6), an anion channel of delayed Ca(2+) activation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TMEM16F is a component of a Ca2+-activated Cl- channel but not a volume-sensitive outwardly rectifying Cl- channel
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anoctamin 6 is an essential component of the outwardly rectifying chloride channel
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl(-) channel
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
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7 January 2021
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inferred from DOI database lookup
Anoctamin 6 differs from VRAC and VSOAC but is involved in apoptosis and supports volume regulation in the presence of Ca2+.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of P2X(7) purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X(7) receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of the P2X₇ receptor in infectious diseases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
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inferred from DOI database lookup
Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Many ways to dilate the P2X7 receptor pore
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The P2X(7) receptor from Xenopus laevis: formation of a large pore in Xenopus oocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characteristics of P2X7 receptors from human B lymphocytes expressed in Xenopus oocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the P2X7 receptor permeability to large molecules by extracellular Cl- and Na+.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of sodium in early phosphatidylserine exposure and phospholipid scrambling induced by P2X7 purinoceptor activation in thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacological properties of a pore induced by raising intracellular Ca2+.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Are second messengers crucial for opening the pore associated with P2X7 receptor?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of TMEM16A (ANO1) and TMEM16F (ANO6) in cell migration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of anoctamins in cancer and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATP-induced killing of mycobacteria by human macrophages is mediated by purinergic P2Z(P2X7) receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pore dilation of neuronal P2X receptor channels
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The P2X7 receptor channel pore dilates under physiological ion conditions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
P2X7 receptor channels allow direct permeation of nanometer-sized dyes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular physiology of P2X receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CrossTalk proposal: Cell volume changes are an essential step in the cell death machinery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of chloride in apoptotic cell death induced by activation of ATP-sensitive P2X7 purinoceptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Volume-activated Cl- channels
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCOMMS7245
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/NCOMMS7245
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1150937
ADS bibcode
2015NatCo...6.6245O
0 references
Dimensions Publication ID
1010496877
0 references
OpenCitations bibliographic resource ID
1150937
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1150937
PubMed publication ID
25651887
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1150937
ResearchGate publication ID
272074068
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