(Q21130016)

Serine/threonine-protein kinase PAK2/3

1 reference

Protein kinase-like domain superfamily

1 reference

p21-activated kinase 2, catalytic domain, protein family

1 reference

p21 activated kinase binding domain, protein family

1 reference

CRIB domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

protein kinase activity

1 reference

8 April 2019

protein tyrosine kinase activator activity

1 reference

8 April 2019

Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

protein serine/threonine kinase activity

8 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177

27 February 2018

Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177

27 February 2018

Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177

27 February 2018

Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177

27 February 2018

VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177

27 February 2018

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177

15 references

8 April 2019

Identification of the Nef-associated kinase as p21-activated kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

Scrib regulates PAK activity during the cell migration process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

betaPIX controls cell motility and neurite extension by regulating the distribution of GIT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

Huntingtin promotes cell survival by preventing Pak2 cleavage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

A human MAP kinase interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

WNT-3a modulates platelet function by regulating small GTPase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

PLC-gamma1 and Rac1 coregulate EGF-induced cytoskeleton remodeling and cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

identical protein binding

1 reference

8 April 2019

A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

2 references

protein kinase binding

1 reference

8 April 2019

Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

27 February 2018

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

protein serine/threonine kinase activity

IPI

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

perinuclear region of cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

negative regulation of protein kinase activity

biological process

1 reference

8 April 2019

Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

cellular response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

stimulatory C-type lectin receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

mitigation of host defenses by virus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

Fc-epsilon receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20

protein phosphorylation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

8 April 2019

Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

dendritic spine development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

1 reference

27 February 2018

Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177

vascular endothelial growth factor receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

peptidyl-serine phosphorylation

1 reference

8 April 2019

Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

positive regulation of extrinsic apoptotic signaling pathway

1 reference

8 April 2019

Huntingtin promotes cell survival by preventing Pak2 cleavage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

protein autophosphorylation

IMP

1 reference

8 April 2019

Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

T cell receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

positive regulation of protein tyrosine kinase activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

negative regulation of apoptotic process

1 reference

8 April 2019

Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

Rho protein signal transduction

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177

regulation of mitotic cell cycle

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

actin cytoskeleton organization

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177

stress-activated protein kinase signaling cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

regulation of MAPK cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

interleukin-12-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

activation of protein kinase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177

negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

346

language of work or name

English

retrieved

17 August 2016

has part(s)

serine/threonine-protein kinase, active site

1 reference

protein kinase domain

1 reference

protein kinase, ATP binding site

1 reference

CRIB domain

1 reference

p21 activated kinase binding domain

1 reference

p21-activated kinase 2, catalytic domain

1 reference