Wikidata

(Q21130508)

English

Component of inhibitor of nuclear factor kappa B kinase complex

mammalian protein found in Homo sapiens

  • I-kappa-B kinase-alpha
  • transcription factor 16
  • IKK1
  • I-kappa-B kinase 1
  • Nuclear factor NF-kappa-B inhibitor kinase alpha
  • IkB kinase alpha subunit
  • Nuclear factor NFkappaB inhibitor kinase alpha
  • IKK-a kinase
  • inhibitor of nuclear factor kappa-B kinase subunit alpha
  • NFKBIKA
  • conserved helix-loop-helix ubiquitous kinase
  • TCF-16
  • CHUK
In more languages

Statements

molecular function
protein binding
determination method
IPI
51 references
retrieved
1 January 2018
stated in
Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha
GOA
curator
UniProt
UniProt protein ID
O15111
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1)
GOA
curator
UniProt
UniProt protein ID
O15111
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling
GOA
curator
UniProt
UniProt protein ID
O15111
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways
GOA
curator
UniProt
UniProt protein ID
O15111
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
GOA
curator
UniProt
UniProt protein ID
O15111
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex
GOA
curator
UniProt
UniProt protein ID
O15111
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth
GOA
curator
UniProt
UniProt protein ID
O15111
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain
GOA
curator
UniProt
UniProt protein ID
O15111
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers
GOA
curator
UniProt
UniProt protein ID
O15111
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Binding of manumycin A inhibits IkappaB kinase beta activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Hepatitis B virus polymerase suppresses NF-κB signaling by inhibiting the activity of IKKs via interaction with Hsp90β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
IκB kinases increase Myc protein stability and enhance progression of breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
NF-κB signalling is attenuated by the E7 protein from cutaneous human papillomaviruses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Viral immune modulators perturb the human molecular network by common and unique strategies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Inhibition of IkappaB kinase by vaccinia virus virulence factor B14
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Functional specialization of beta-arrestin interactions revealed by proteomic analysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Theileria-induced constitutive IKK activation is independent of functional Hsp90
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
retrieved
1 January 2018
stated in
A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111
determination method
IPI
cell component
biological process

Identifiers

 
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