Wikidata

(Q21131475)

English

Eukaryotic translation initiation factor 4A3

mammalian protein found in Homo sapiens

  • ATP-dependent RNA helicase eIF4A-3
  • Eukaryotic translation initiation factor 4A isoform 3
  • nuclear matrix protein 265
  • eukaryotic initiation factor 4A-III
  • eukaryotic translation initiation factor 4A
  • EIF4A3
  • eukaryotic initiation factor 4A-like NUK-34
  • ATP-dependent RNA helicase DDX48
  • DEAD box protein 48
  • eIF4A-III
  • eIF-4A-III
  • NMP 265
  • hNMP 265
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 48
In more languages

Statements

molecular function
protein binding
determination method
IPI
25 references
retrieved
8 April 2019
stated in
SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs
GOA
curator
UniProt
UniProt protein ID
P38919
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly
GOA
curator
UniProt
UniProt protein ID
P38919
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3
GOA
curator
UniProt
UniProt protein ID
P38919
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
eIF4G is required for the pioneer round of translation in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
Dynamic protein-protein interaction wiring of the human spliceosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
eIF4A3 is a novel component of the exon junction complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
Disassembly of exon junction complexes by PYM
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
retrieved
8 April 2019
stated in
Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38919
determination method
IPI
cell component
biological process

Identifiers

 
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