(Q21135165)

http://www.ebi.ac.uk/interpro/protein/P63146

Ubiquitin-conjugating enzyme E2 family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin-conjugating enzyme, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

ubiquitin protein ligase activity

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63146&geneProductId=UniProtKB:P63146

ubiquitin-protein transferase activity

IBA

4 references

8 April 2019

Rad6B is a positive regulator of beta-catenin stabilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

8 April 2019

Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

8 April 2019

Direct characterization of E2-dependent target specificity and processivity using an artificial p27-linker-E2 ubiquitination system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

8 April 2019

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

5 references

8 April 2019

ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

8 April 2019

A human protein-protein interaction network: a resource for annotating the proteome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

8 April 2019

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

8 April 2019

UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

8 April 2019

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

ubiquitin conjugating enzyme activity

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63146&geneProductId=UniProtKB:P63146

ubiquitin protein ligase binding

3 references

8 April 2019

The human RAD18 gene product interacts with HHR6A and HHR6B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

8 April 2019

Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

1 reference

8 April 2019

Rad6B is a positive regulator of beta-catenin stabilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

1 reference

8 April 2019

Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

1 reference

16 July 2018

RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63146&geneProductId=UniProtKB:P63146

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

histone H2A ubiquitination

1 reference

8 April 2019

Rad6B is a positive regulator of beta-catenin stabilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

negative regulation of cAMP-mediated signaling

1 reference

8 April 2019

Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

postreplication repair

NAS

ubiquitin-dependent protein catabolic process

NAS

protein K63-linked ubiquitination

1 reference

8 April 2019

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

meiotic telomere clustering

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

positive regulation of reciprocal meiotic recombination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

Rad6B is a positive regulator of beta-catenin stabilization

protein stabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

protein polyubiquitination

1 reference

16 July 2018

Rad6B is a positive regulator of beta-catenin stabilization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63146&geneProductId=UniProtKB:P63146

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

in utero embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

protein monoubiquitination

1 reference

8 April 2019

Rad6B is a positive regulator of beta-catenin stabilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

sperm axoneme assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

protein K11-linked ubiquitination

1 reference

8 April 2019

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

histone lysine demethylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

protein K48-linked ubiquitination

1 reference

8 April 2019

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

regulation of histone modification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

synaptonemal complex organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

1 reference

8 April 2019

Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

proteasome-mediated ubiquitin-dependent protein catabolic process

IGI

1 reference

16 July 2018

Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63146&geneProductId=UniProtKB:P63146

protein autoubiquitination

1 reference

8 April 2019

Direct characterization of E2-dependent target specificity and processivity using an artificial p27-linker-E2 ubiquitination system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

protein ubiquitination

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

8 April 2019

Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

8 April 2019

Direct characterization of E2-dependent target specificity and processivity using an artificial p27-linker-E2 ubiquitination system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

3 references

8 April 2019

Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63146

proteasome-mediated ubiquitin-dependent protein catabolic process

IBA

Ubiquitin-conjugating enzyme E2

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63146

Ubiquitin-conjugating enzyme, active site

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63146

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016