(Q21135733)

English

Sulfatase 2

mammalian protein found in Homo sapiens

SULF2
extracellular sulfatase Sulf-2

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Extracellular sulfatase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWU5

Alkaline-phosphatase-like, core domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWU5

Sulfatase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Extracellular sulfatase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

calcium ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

catalytic activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

sulfuric ester hydrolase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

N-acetylglucosamine-6-sulfatase activity

determination method

3 references

27 March 2018

Functional consequences of the subdomain organization of the sulfs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

27 March 2018

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

glycosaminoglycan binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

N-acetylglucosamine-6-sulfatase activity

determination method

4 references

8 April 2019

Functional consequences of the subdomain organization of the sulfs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

determination method

5 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

27 March 2018

Functional consequences of the subdomain organization of the sulfs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

27 March 2018

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

27 March 2018

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

endoplasmic reticulum

determination method

3 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

27 March 2018

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

extracellular space

determination method

1 reference

8 April 2019

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

endoplasmic reticulum

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

plasma membrane

determination method

3 references

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Functional consequences of the subdomain organization of the sulfs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

biological process

positive regulation of canonical Wnt signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

positive regulation of Wnt signaling pathway

determination method

1 reference

1 January 2018

Functional consequences of the subdomain organization of the sulfs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

negative regulation of fibroblast growth factor receptor signaling pathway

determination method

liver regeneration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

response to wounding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

regulation of hepatocyte proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

heparan sulfate proteoglycan metabolic process

determination method

3 references

27 March 2018

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

27 March 2018

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU5&geneProductId=UniProtKB:Q8IWU5

determination method

chondrocyte development

determination method

3 references

glomerular filtration

determination method

3 references

positive regulation of vascular endothelial growth factor production

determination method

3 references

esophagus smooth muscle contraction

determination method

3 references

heparan sulfate proteoglycan metabolic process

determination method

4 references

8 April 2019

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

glomerular basement membrane development

determination method

3 references

glial cell-derived neurotrophic factor receptor signaling pathway

determination method

3 references

negative regulation of fibroblast growth factor receptor signaling pathway

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU5

determination method

embryonic skeletal system development

determination method

3 references

bone development

determination method

determination method

3 references

Sulfatase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWU5

Extracellular sulfatase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWU5

Sulfatase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWU5

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000353007

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353007

ENSP00000418290

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418290

ENSP00000418442

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418442

ENSP00000410026

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000410026

ENSP00000417894

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417894

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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