(Q21135734)

English

Sulfatase 1

mammalian protein found in Homo sapiens

extracellular sulfatase Sulf-1
SULF1
sulfatase FP

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Extracellular sulfatase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWU6

Alkaline-phosphatase-like, core domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWU6

Sulfatase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Extracellular sulfatase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

N-acetylglucosamine-6-sulfatase activity

determination method

4 references

26 September 2017

Functional consequences of the subdomain organization of the sulfs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

sulfuric ester hydrolase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

calcium ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

catalytic activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

glycosaminoglycan binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

N-acetylglucosamine-6-sulfatase activity

determination method

5 references

8 April 2019

Functional consequences of the subdomain organization of the sulfs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

endoplasmic reticulum

determination method

3 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

determination method

1 reference

8 April 2019

Functional consequences of the subdomain organization of the sulfs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

determination method

6 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Functional consequences of the subdomain organization of the sulfs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

Golgi apparatus

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

extracellular space

determination method

3 references

26 September 2017

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

extracellular space

determination method

4 references

1 January 2018

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

1 January 2018

Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

1 January 2018

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

endoplasmic reticulum

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

plasma membrane

determination method

3 references

determination method

7 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Functional consequences of the subdomain organization of the sulfs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

collagen-containing extracellular matrix

determination method

1 reference

8 April 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

extracellular space

determination method

3 references

8 April 2019

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

biological process

negative regulation of angiogenesis

determination method

1 reference

8 April 2019

HSulf-1 inhibits angiogenesis and tumorigenesis in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

heparan sulfate proteoglycan metabolic process

determination method

5 references

26 September 2017

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

regulation of fibroblast growth factor receptor signaling pathway

determination method

1 reference

8 April 2019

HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

negative regulation of fibroblast growth factor receptor signaling pathway

determination method

3 references

26 September 2017

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

negative regulation of endothelial cell proliferation

determination method

1 reference

8 April 2019

HSulf-1 inhibits angiogenesis and tumorigenesis in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

positive regulation of Wnt signaling pathway

determination method

1 reference

26 September 2017

Functional consequences of the subdomain organization of the sulfs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

vascular endothelial growth factor receptor signaling pathway

determination method

1 reference

8 April 2019

HSulf-1 inhibits angiogenesis and tumorigenesis in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

apoptotic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6

determination method

positive regulation of BMP signaling pathway

determination method

1 reference

8 April 2019

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

negative regulation of cell migration

determination method

1 reference

8 April 2019

HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

chondrocyte development

determination method

3 references

glomerular filtration

determination method

3 references

positive regulation of vascular endothelial growth factor production

determination method

3 references

esophagus smooth muscle contraction

determination method

3 references

heparan sulfate proteoglycan metabolic process

determination method

6 references

8 April 2019

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

glomerular basement membrane development

determination method

3 references

glial cell-derived neurotrophic factor receptor signaling pathway

determination method

3 references

negative regulation of fibroblast growth factor receptor signaling pathway

determination method

4 references

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6

determination method

embryonic skeletal system development

determination method

3 references

bone development

determination method

determination method

3 references

Extracellular sulfatase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWU6

Sulfatase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWU6

Sulfatase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWU6

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000260128

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000260128

ENSP00000385704

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000385704

ENSP00000390315

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000390315

ENSP00000403040

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000403040

ENSP00000431308

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000431308

ENSP00000431753

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000431753

ENSP00000432178

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432178

ENSP00000434128

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434128

ENSP00000436608

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000436608

ENSP00000436949

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000436949

ENSP00000480454

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000480454

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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