(Q21136126)

http://www.ebi.ac.uk/interpro/protein/P35610

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2

fatty-acyl-CoA binding

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

sterol O-acyltransferase activity

3 references

8 April 2019

Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

O-acyltransferase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

1 reference

10 September 2018

A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

acyltransferase activity

1 reference

8 April 2019

cholesterol O-acyltransferase activity

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

27 March 2018

Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

27 March 2018

A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

cholesterol O-acyltransferase activity

6 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

7 November 2018

Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

7 November 2018

A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

cholesterol O-acyltransferase activity

fatty-acyl-CoA binding

5 references

8 April 2019

Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

endoplasmic reticulum

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

endoplasmic reticulum membrane

3 references

endoplasmic reticulum membrane

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

Knockdown of ACAT-1 reduces amyloidogenic processing of APP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

steroid metabolic process

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

macrophage derived foam cell differentiation

3 references

8 April 2019

Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

cholesterol metabolic process

5 references

27 March 2018

Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

27 March 2018

ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

27 March 2018

A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

cholesterol esterification

3 references

10 September 2018

Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

10 September 2018

A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

1 reference

8 April 2019

Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

1 reference

10 September 2018

Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35610&geneProductId=UniProtKB:P35610

positive regulation of amyloid precursor protein biosynthetic process

IMP

1 reference

8 April 2019

Knockdown of ACAT-1 reduces amyloidogenic processing of APP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

very-low-density lipoprotein particle assembly

IMP

1 reference

8 April 2019

Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

low-density lipoprotein particle clearance

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

cholesterol metabolic process

TAS

6 references

8 April 2019

Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

2 references

8 April 2019

Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

cholesterol esterification

4 references

8 April 2019

Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35610