(Q24322278)

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A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2

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scholarly article

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A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2 (English)

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Sterol O-acyltransferase 1

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GOA release 2020-03-11

Sterol O-acyltransferase 2

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GOA release 2020-03-11

cholesterol O-acyltransferase activity

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GOA release 2020-03-11

author name string

Sojin An

1

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Kyung-Hyun Cho

2

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Woo Song Lee

3

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Jie-Oh Lee

4

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Young-Ki Paik

5

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Tae-Sook Jeong

6

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language of work or name

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publication date

15 May 2006

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580

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11

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2741-9

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Acyl-coenzyme A:cholesterol acyltransferase

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ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization

1 reference

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Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol

1 reference

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Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1

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Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation

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Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness

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Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes

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The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain

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Human acyl-coenzyme A:cholesterol acyltransferase expressed in chinese hamster ovary cells: membrane topology and active site location

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Regulation of lecithin cholesterol acyltransferase activity

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Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits

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Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas

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A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling

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Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains

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Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest

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A proposed architecture for lecithin cholesterol acyl transferase (LCAT): identification of the catalytic triad and molecular modeling

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Site-directed mutagenesis of active site residues of phosphite dehydrogenase

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Substrate positioning by His92 is important in catalysis by purple acid phosphatase

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Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase. Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181, His184.

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Structural evidence for dimerization-regulated activation of an integral membrane phospholipase

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A conserved histidine residue of Escherichia coli outer-membrane phospholipase A is important for activity

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Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2.

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7 January 2021

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10.1016/J.FEBSLET.2006.04.035

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