(Q28245277)

title

Acyl-coenzyme A:cholesterol acyltransferase (English)

0 references

author name string

T. Y. Chang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9242919

9 November 2024

C. C. Chang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9242919

9 November 2024

D. Cheng

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9242919

full work available at URL

9 November 2024

language of work or name

English

0 references

publication date

1997

0 references

https://www.annualreviews.org/doi/pdf/10.1146/annurev.biochem.66.1.613

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Annual Review of Biochemistry

9 November 2024

published in

0 references

volume

66

0 references

page(s)

613-38

0 references

cites work

Molecular biology of enzymes involved with cholesterol ester hydrolysis in mammalian tissues

3

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Physical-Chemical Basis of Lipid Deposition in Atherosclerosis

9 November 2024

4

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Journal of Biological Chemistry

9 November 2024

7

250

4925

Brown MS

1975

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia

9 November 2024

8

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Cholesteryl ester metabolism in atherosclerotic arterial tissue

9 November 2024

9

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Studies of the mechanism of augmented synthesis of cholesteryl ester in atherosclerotic rabbit aortic microsomes

9 November 2024

10

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Properties of acyl-CoA:cholesterol O-acyltransferase in aortic microsomes from atherosclerotic rabbits

9 November 2024

11

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Development of intracellular lipid deposits in the lipid-laden cells of atherosclerotic lesions. A cytochemical and ultrastructural study

9 November 2024

14

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis

9 November 2024

15

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation

9 November 2024

19

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

The stimulation of the cholesterol esterification pathway by atherogenic lipoproteins in macrophages

9 November 2024

20

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Intestinal lipoprotein synthesis and secretion

9 November 2024

24

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents

9 November 2024

25

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Role of acylcoenzyme A: Cholesterol o-acyltransferase in cholesterol metabolism

9 November 2024

26

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Regulation and immunolocalization of acyl-coenzyme A: cholesterol acyltransferase in mammalian cells as studied with specific antibodies

9 November 2024

35

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Influence of high density lipoprotein on esterified cholesterol stores in macrophages and hepatoma cells

9 November 2024

39

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Species difference in cholesteryl ester cycle and HDL-induced cholesterol efflux from macrophage foam cells

9 November 2024

40

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Cell toxicity induced by inhibition of acyl coenzyme A:cholesterol acyltransferase and accumulation of unesterified cholesterol

9 November 2024

42

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Rat-liver acyl-CoA: cholesterol acyltransferase

9 November 2024

45

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Solubilization, partial purification, and reconstitution in phosphatidylcholine-cholesterol liposomes of acyl-CoA:cholesterol acyltransferase

9 November 2024

49

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Acyl-CoA:cholesterol acyltransferase in Chinese hamster ovary cells. Enzyme activity determined after reconstitution in phospholipid/cholesterol liposomes

9 November 2024

50

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Defective activity of acyl-CoA:cholesterol O-acyltransferase in Niemann-Pick type C and type D fibroblasts

9 November 2024

51

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Differences in the potency of ACAT inhibitors in two assay systems

9 November 2024

52

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Effect of membrane environment on inhibition of acyl-CoA:cholesterol acyltransferase by a range of synthetic inhibitors

9 November 2024

53

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Activation of acyl-coenzyme A:cholesterol acyltransferase activity by cholesterol is not due to altered mRNA levels in HepG2 cells

9 November 2024

54

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Chemical modification of acyl-CoA:cholesterol O-acyltransferase. 1. Identification of acyl-CoA:cholesterol O-acyltransferase subtypes by differential diethyl pyrocarbonate sensitivity.

9 November 2024

55

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Chemical modification of acyl-CoA:cholesterol O-acyltransferase. 2. Identification of a coenzyme A regulatory site by p-mercuribenzoate modification

9 November 2024

56

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

12-[(5-iodo-4-azido-2-hydroxybenzoyl)amino]dodecanoic acid: biological recognition by cholesterol esterase and acyl-CoA:cholesterol O-acyltransferase

9 November 2024

57

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Isolation of Chinese hamster ovary cell lines expressing human acyl-coenzyme A/cholesterol acyltransferase activity

9 November 2024

59

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Activation of acyl-coenzyme A:cholesterol acyltransferase by cholesterol or by oxysterol in a cell-free system

9 November 2024

61

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Molecular cloning and characterization of two isoforms of Saccharomyces cerevisiae acyl-CoA:sterol acyltransferase

9 November 2024

62

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Sterol esterification in yeast: a two-gene process

9 November 2024

64

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro

9 November 2024

66

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Complementation of mutation in acyl-CoA:cholesterol acyltransferase (ACAT) fails to restore sterol regulation in ACAT-defective sterol-resistant hamster cells

9 November 2024

67

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Cloning and expression in Xenopus oocytes of a mouse homologue of the human acylcoenzyme A: cholesterol acyltransferase and its potential role in metabolism of oxidized LDL.

9 November 2024

69

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Acyl-coenzyme A:cholesterol O-acyltransferase is not identical to liver microsomal carboxylesterase

9 November 2024

70

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase

9 November 2024

71

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl:adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA thioesterases

9 November 2024

72

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Sebaceous Gland Differentiation: II. The Isolation, Separation and Characterization of Cells from the Mouse Preputial Gland

9 November 2024

75

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals

9 November 2024

79

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Localization of acyl coenzyme A:cholesterol acyltransferase gene to human chromosome 1q25

9 November 2024

81

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Genetic and biochemical studies of the adrenal lipid depletion phenotype in mice

9 November 2024

82

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

9 November 2024

86

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Cycloheximide sensitivity in regulation of acyl coenzyme A:cholesterol acyltransferase activity in Chinese hamster ovary cells. 1. Effect of exogenous sterols

9 November 2024

87

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Cycloheximide sensitivity in regulation of acyl coenzyme A:cholesterol acyltransferase activity in Chinese hamster ovary cells. 2. Effect of sterol endogenously synthesized

9 November 2024

88

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Effect and Cellular Site of Action of Cysteine Protease Inhibitors on the Cholesterol Esterification Pathway in Macrophages and Chinese Hamster Ovary Cells

9 November 2024

90

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Gene expression of acyl-coenzyme-A:cholesterol-acyltransferase is upregulated in human monocytes during differentiation and foam cell formation

9 November 2024

91

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Allosteric proteins and cellular control systems

9 November 2024

96

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

The Catalytic and Regulatory Properties of Enzymes

9 November 2024

97

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Phospholipid fatty acid modification of rat liver microsomes affects acylcoenzyme A:cholesterol acyltransferase activity

9 November 2024

99

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Dexamethasone enhances accumulation of cholesteryl esters by human macrophages

9 November 2024

100

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Acyl-coenzyme A: cholesterol acyltransferase. Transfer of cholesterol to its substrate pool and modulation of activity

9 November 2024

101

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Conditions that may result in (de-)phosphorylation of hepatic acyl-CoA:cholesterol acyltransferase result also in modulation of substrate supply in vitro

9 November 2024

102

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

The role of plasma membranes in the transfer of non-esterified cholesterol to the acyl-CoA:cholesterol acyltransferase substrate pool in liver microsomal fraction

9 November 2024

103

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Regulation of the mevalonate pathway

9 November 2024

105

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum

9 November 2024

106

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane

9 November 2024

110

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

9 November 2024

111

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Cellular free cholesterol in Hep G2 cells is only partially available for down-regulation of low-density-lipoprotein receptor activity

9 November 2024

112

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Cholesterol esterification plays a major role in determining low-density-lipoprotein receptor activity in primary monolayer cultures of rat hepatocytes

9 November 2024

113

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools

9 November 2024

114

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Oleate and other long chain fatty acids stimulate low density lipoprotein receptor activity by enhancing acyl coenzyme A:cholesterol acyltransferase activity and altering intracellular regulatory cholesterol pools in cultured cells

9 November 2024

115

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

A receptor-mediated pathway for cholesterol homeostasis

9 November 2024

116

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Intracellular cholesterol transport and compartmentation

9 November 2024

119

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Compartmental isolation of cholesterol participating in the cytoplasmic cholesteryl ester cycle in Chinese hamster ovary 25-RA cells

9 November 2024

120

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Cholesterol movement between the plasma membrane and the cholesteryl ester droplets of cultured Leydig tumour cells

9 November 2024

121

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

The role of intracellular cholesterol transport in cholesterol homeostasis

9 November 2024

122

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Intracellular cholesterol transport

9 November 2024

123

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Mechanisms and consequences of cellular cholesterol exchange and transfer.

9 November 2024

124

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

The NP-C gene: a key to pathways of intracellular cholesterol transport

9 November 2024

125

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Effect of cholesterol transport inhibitors on steroidogenesis and plasma membrane cholesterol transport in cultured MA-10 Leydig tumor cells

9 November 2024

126

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Intracellular trafficking of cholesterol monitored with a cyclodextrin

9 November 2024

129

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Acidification of the endocytic and exocytic pathways

9 November 2024

132

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Type-C Niemann-Pick disease: low density lipoprotein uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes

9 November 2024

133

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Isolation and characterization of Chinese hamster ovary cell mutants defective in intracellular low density lipoprotein-cholesterol trafficking

9 November 2024

134

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Translocation of both lysosomal LDL-derived cholesterol and plasma membrane cholesterol to the endoplasmic reticulum for esterification may require common cellular factors involved in cholesterol egress from the acidic compartments (lysosomes/endoso

9 November 2024

135

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

A defect in cholesterol esterification in Niemann-Pick disease (type C) patients

9 November 2024

136

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Niemann-Pick type II fibroblasts exhibit impaired cholesterol esterification in response to sphingomyelin hydrolysis

9 November 2024

137

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Journal of Biological Chemistry

9 November 2024

138

96

1273

McGookey DJ

1983

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Phospholipid, cholesterol, polypeptide and glycoprotein composition of hepatic endosome subfractions

9 November 2024

139

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts

9 November 2024

140

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Cholesterol and the Golgi apparatus

9 November 2024

146

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

9 November 2024

147

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Stimulation of acyl-CoA:cholesterol acyltransferase activity by brefeldin A in macrophage J774 cells

9 November 2024

148

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Inhibition of acyl-CoA:cholesterol acyltransferase in Chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide

9 November 2024

149

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Transport of cholesterol from the endoplasmic reticulum to the plasma membrane

9 November 2024

150

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Cholesterol and vesicular stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane

9 November 2024

151

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Sterol carrier protein-2 is involved in cholesterol transfer from the endoplasmic reticulum to the plasma membrane in human fibroblasts.

9 November 2024

153

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane

9 November 2024

154

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Is plasma membrane lipid composition defined in the exocytic or the endocytic pathway?

9 November 2024

155

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation

9 November 2024

156

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

VIP21/caveolin is a cholesterol-binding protein

9 November 2024

157

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Expression and Characterization of Recombinant Caveolin

9 November 2024

158

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Plasma membrane caveolae mediate the efflux of cellular free cholesterol

9 November 2024

159

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Role of an N-ethylmaleimide-sensitive factor in the selective cellular uptake of low-density lipoprotein free cholesterol

9 November 2024

160

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Spontaneous and protein-mediated sterol transfer between intracellular membranes

9 November 2024

161

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Progesterone inhibits cholesterol biosynthesis in cultured cells. Accumulation of cholesterol precursors

9 November 2024

166

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Role of multidrug resistance P-glycoproteins in cholesterol biosynthesis

9 November 2024

167

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

n-3 and n-6 polyunsaturated fatty acids have different effects on acyl-CoA:cholesterol acyltransferase in J774 macrophages

9 November 2024

170

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids

9 November 2024

171

1 reference

https://api.crossref.org/works/10.1146/ANNUREV.BIOCHEM.66.1.613

9 November 2024

Identifiers

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017