(Q21151082)

http://www.ebi.ac.uk/interpro/protein/P02671

Fibrinogen alpha chain

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02671

Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain, protein family

1 reference

Fibrinogen, alpha/beta/gamma chain, coiled coil domain, protein family

1 reference

Fibrinogen alpha C domain, protein family

1 reference

Fibrinogen, conserved site, protein family

1 reference

protein-macromolecule adaptor activity

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

6 references

26 September 2017

Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

26 September 2017

An investigation into the human serum "interactome"

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

26 September 2017

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

26 September 2017

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

26 September 2017

A Single Kinase Generates the Majority of the Secreted Phosphoproteome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

26 September 2017

Fibrinogen Magdeburg I: a novel variant of human fibrinogen with an amino acid exchange in the fibrinopeptide A (Aα 9, Leu→Pro)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

cell adhesion molecule binding

IPI

1 reference

26 September 2017

A mitogenic action for fibrinogen mediated through intercellular adhesion molecule-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets

cell component

platelet alpha granule

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset

extracellular vesicle

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

5 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

26 September 2017

The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

26 September 2017

Congenital hypofibrinogenemia: characterization of two missense mutations affecting fibrinogen assembly and secretion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

26 September 2017

The role of betagamma and alphagamma complexes in the assembly of human fibrinogen

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

26 September 2017

The human plasma proteome: a nonredundant list developed by combination of four separate sources

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

1 reference

26 September 2017

Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

extracellular exosome

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

platelet alpha granule lumen

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

external side of plasma membrane

1 reference

26 September 2017

Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

1 reference

26 September 2017

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

1 reference

26 September 2017

Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

endoplasmic reticulum lumen

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

negative regulation of endothelial cell apoptotic process

1 reference

26 September 2017

Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

positive regulation of peptide hormone secretion

1 reference

26 September 2017

Fibrinogen-induced endothelin-1 production from endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

positive regulation of heterotypic cell-cell adhesion

1 reference

26 September 2017

Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

adaptive immune response

1 reference

26 September 2017

1 reference

26 September 2017

The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

immune system process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

platelet degranulation

1 reference

26 September 2017

extracellular matrix organization

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets

response to calcium ion

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

positive regulation of substrate adhesion-dependent cell spreading

1 reference

26 September 2017

The role of fibrin matrices and tissue factor in early-term trophoblast proliferation and spreading

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

blood coagulation, common pathway

NAS

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

IMP

1 reference

26 September 2017

Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

positive regulation of vasoconstriction

1 reference

26 September 2017

Fibrinogen and fragment D-induced vascular constriction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

positive regulation of protein secretion

1 reference

26 September 2017

Fibrinogen-induced endothelin-1 production from endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

negative regulation of blood coagulation, common pathway

1 reference

26 September 2017

The dysfibrinogenaemias

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

positive regulation of exocytosis

1 reference

26 September 2017

Fibrinogen-induced endothelin-1 production from endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

blood coagulation, fibrin clot formation

1 reference

26 September 2017

The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance

plasminogen activation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

1 reference

26 September 2017

Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

innate immune response

1 reference

26 September 2017

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

induction of bacterial agglutination

1 reference

26 September 2017

The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

toll-like receptor signaling pathway

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

post-translational protein modification

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671

physically interacts with

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201505

Identifiers

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30 May 2020

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30 May 2020

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13 November 2019

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9 August 2016

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9 August 2016