(Q21154133)

English

LIM domain kinase 1

mammalian protein found in Homo sapiens

LIMK1
LIM motif-containing protein kinase
KIZ-1

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53667

PDZ superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53667

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, LIM-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

PDZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

heat shock protein binding

determination method

1 reference

8 April 2019

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

protein binding

determination method

13 references

8 April 2019

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Protein-protein interaction of zinc finger LIM domains with protein kinase C

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

determination method

2 references

protein serine/threonine kinase activity

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

signal transducer activity

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53667&geneProductId=UniProtKB:P53667

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

determination method

3 references

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53667&geneProductId=UniProtKB:P53667

determination method

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53667&geneProductId=UniProtKB:P53667

determination method

5 June 2018

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53667&geneProductId=UniProtKB:P53667

determination method

determination method

3 references

Golgi apparatus

determination method

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53667&geneProductId=UniProtKB:P53667

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

neuron projection

determination method

3 references

determination method

cell projection

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

biological process

Fc-gamma receptor signaling pathway involved in phagocytosis

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

nervous system development

determination method

1 reference

8 April 2019

LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

negative regulation of ubiquitin-protein transferase activity

determination method

1 reference

8 April 2019

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

Rho protein signal transduction

determination method

1 reference

8 April 2019

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

positive regulation of actin filament bundle assembly

determination method

1 reference

8 April 2019

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

actin cytoskeleton organization

determination method

1 reference

5 June 2018

Signal-regulated activation of serum response factor is mediated by changes in actin dynamics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53667&geneProductId=UniProtKB:P53667

determination method

protein phosphorylation

determination method

4 references

8 April 2019

Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

8 April 2019

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53667

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53667

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53667

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53667

Zinc finger, LIM-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53667

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000336740

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000336740

ENSP00000414606

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000414606

ENSP00000444452

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000444452

ENSP00000409717

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000409717

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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