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(Q21154422)
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Suppressor of cytokine signaling 3
mammalian protein found in Homo sapiens
SSI-3
STAT-induced STAT inhibitor 3
suppressor of cytokine signaling 3
cytokine-inducible SH2 protein 3
SOCS3
CIS-3
Suppressor of Cytokine Signaling 3 Protein
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O14543
subclass of
protein
1 reference
stated in
UniProt
retrieved
1 December 2016
UniProt protein ID
O14543
part of
suppressor of cytokine signalling 3
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O14543
SOCS box-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O14543
SH2 domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O14543
SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SOCS box domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SOCS3, SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O14543
encoded by
SOCS3
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O14543
molecular function
protein kinase inhibitor activity
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
TAS
protein binding
determination method
IPI
4 references
retrieved
8 April 2019
stated in
PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IPI
retrieved
8 April 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IPI
retrieved
8 April 2019
stated in
The role of microtubule-associated protein 1S in SOCS3 regulation of IL-6 signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IPI
phosphotyrosine residue binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
1-phosphatidylinositol-3-kinase regulator activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IBA
cell component
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
TAS
cytoplasm
determination method
IBA
1 reference
retrieved
31 January 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14543&geneProductId=UniProtKB:O14543
determination method
IBA
phosphatidylinositol 3-kinase complex
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IBA
biological process
regulation of protein phosphorylation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
trophoblast giant cell differentiation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
intracellular signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
spongiotrophoblast differentiation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
placenta blood vessel development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
negative regulation of apoptotic process
determination method
IEA
TAS
2 references
retrieved
8 April 2019
stated in
Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
negative regulation of insulin receptor signaling pathway
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IBA
regulation of interferon-gamma-mediated signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
TAS
branching involved in labyrinthine layer morphogenesis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
protein ubiquitination
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O14543
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
positive regulation of cell differentiation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
regulation of cell differentiation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
regulation of growth
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O14543
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
negative regulation of signal transduction
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O14543
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
negative regulation of inflammatory response
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
negative regulation of protein kinase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
negative regulation of receptor signaling pathway via JAK-STAT
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
MiR-221 accentuates IFN׳s anti-HCV effect by downregulating SOCS1 and SOCS3
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IMP
negative regulation of tyrosine phosphorylation of STAT protein
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
MiR-221 accentuates IFN׳s anti-HCV effect by downregulating SOCS1 and SOCS3
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IMP
post-translational protein modification
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
TAS
cellular response to leukemia inhibitory factor
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
positive regulation of tyrosine phosphorylation of STAT protein
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
TAS
receptor signaling pathway via JAK-STAT
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
cytokine-mediated signaling pathway
determination method
IBA
TAS
2 references
retrieved
31 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14543&geneProductId=UniProtKB:O14543
determination method
TAS
retrieved
31 January 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14543&geneProductId=UniProtKB:O14543
determination method
IBA
interleukin-6-mediated signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
TAS
cytokine-mediated signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
TAS
regulation of phosphatidylinositol 3-kinase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IEA
phosphatidylinositol phosphate biosynthetic process
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14543
determination method
IBA
has part(s)
SOCS box domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O14543
SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O14543
SOCS3, SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O14543
Identifiers
RefSeq protein ID
NP_003946
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
9021
NP_001365861
1 reference
stated in
NCBI Gene
retrieved
4 April 2020
Entrez Gene ID
9021
NP_001365862
1 reference
stated in
NCBI Gene
retrieved
4 April 2020
Entrez Gene ID
9021
UniProt protein ID
O14543
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O14543
Ensembl protein ID
ENSP00000330341
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000330341
ENSP00000464727
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000464727
PDB structure ID
2BBU
1 reference
stated in
Swiss-Prot
UniProt
retrieved
10 November 2015
reference URL
http://www.uniprot.org/uniprot/O35718.txt?version=143
2HMH
1 reference
stated in
Swiss-Prot
UniProt
retrieved
10 November 2015
reference URL
http://www.uniprot.org/uniprot/O35718.txt?version=143
2JZ3
1 reference
stated in
Swiss-Prot
UniProt
retrieved
10 November 2015
reference URL
http://www.uniprot.org/uniprot/O35718.txt?version=143
4GL9
1 reference
stated in
Swiss-Prot
UniProt
retrieved
10 November 2015
reference URL
http://www.uniprot.org/uniprot/O35718.txt?version=143
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