(Q21171707)

http://www.ebi.ac.uk/interpro/protein/Q9ULM6

Leucine-rich repeat domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ULM6

membrane protein

1 reference

inferred from GOA cell component → membrane

CCR4-NOT transcription complex subunit 6, protein family

1 reference

Endonuclease/exonuclease/phosphatase family

1 reference

Leucine-rich repeat, typical subtype, protein family

1 reference

Leucine-rich repeat, protein family

1 reference

poly(A)-specific ribonuclease activity

1 reference

16 January 2019

1 reference

16 January 2019

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

8 April 2019

Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

8 April 2019

CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase

IDA

exoribonuclease activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

8 references

9 May 2019

Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

3'-5'-exoribonuclease activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

poly(A)-specific ribonuclease activity

IBA

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

1 reference

26 September 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULM6&geneProductId=UniProtKB:Q9ULM6

1 reference

8 April 2019

Human Ccr4-Not complexes contain variable deadenylase subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

1 reference

9 May 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

regulation of transcription, DNA-templated

HDA

biological process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULM6&geneProductId=UniProtKB:Q9ULM6

nucleic acid phosphodiester bond hydrolysis

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

transcription, DNA-templated

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULM6&geneProductId=UniProtKB:Q9ULM6

positive regulation of cytoplasmic mRNA processing body assembly

1 reference

9 May 2019

The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells

IMP

gene silencing by miRNA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

positive regulation of cell population proliferation

TAS

1 reference

9 May 2019

The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

exonucleolytic catabolism of deadenylated mRNA

IMP

1 reference

9 May 2019

CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

nuclear-transcribed mRNA catabolic process, no-go decay

1 reference

9 May 2019

UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

regulation of translation

IMP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

RNA phosphodiester bond hydrolysis, exonucleolytic

TAS

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

nuclear-transcribed mRNA poly(A) tail shortening

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULM6