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(Q21172876)
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Suppressor of cytokine signaling 4
mammalian protein found in Homo sapiens
suppressor of cytokine signaling 4
SOCS4
suppressor of cytokine signaling 7
SOCS-7
SOCS-4
SH2 domain containing SOCS box protein
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8WXH5
subclass of
protein
1 reference
stated in
UniProt
retrieved
1 December 2016
UniProt protein ID
Q8WXH5
part of
Suppressor of cytokine signalling 4
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8WXH5
SOCS box-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8WXH5
SH2 domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8WXH5
SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SOCS4, SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SOCS4, SOCS box domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SOCS4/SOCS5 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SOCS box domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8WXH5
encoded by
SOCS4
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8WXH5
molecular function
protein kinase inhibitor activity
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WXH5&geneProductId=UniProtKB:Q8WXH5
determination method
IBA
protein binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXH5
determination method
IPI
cell component
cytoplasm
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WXH5&geneProductId=UniProtKB:Q8WXH5
determination method
IBA
intracellular anatomical structure
determination method
IEA
1 reference
retrieved
10 September 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WXH5&geneProductId=UniProtKB:Q8WXH5
determination method
IEA
biological process
negative regulation of epidermal growth factor-activated receptor activity
determination method
IDA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXH5
determination method
IEA
retrieved
8 April 2019
stated in
Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling
GOA
curator
UniProt
UniProt protein ID
Q8WXH5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXH5
determination method
IDA
regulation of growth
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8WXH5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXH5
determination method
IEA
negative regulation of signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8WXH5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXH5
determination method
IEA
intracellular signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXH5
determination method
IEA
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXH5
determination method
IEA
protein ubiquitination
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8WXH5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXH5
determination method
IEA
cytokine-mediated signaling pathway
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WXH5&geneProductId=UniProtKB:Q8WXH5
determination method
IBA
negative regulation of receptor signaling pathway via JAK-STAT
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WXH5&geneProductId=UniProtKB:Q8WXH5
determination method
IBA
has part(s)
SOCS box domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8WXH5
SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8WXH5
SOCS4/SOCS5 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8WXH5
SOCS4, SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8WXH5
SOCS4, SOCS box domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8WXH5
Identifiers
RefSeq protein ID
NP_543143
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
122809
NP_955453
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
122809
XP_011534727
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
122809
XP_011534728
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
122809
UniProt protein ID
Q8WXH5
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8WXH5
Ensembl protein ID
ENSP00000341327
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000341327
ENSP00000378855
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000378855
ENSP00000452522
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000452522
PDB structure ID
2IZV
1 reference
stated in
UniProt
UniProt protein ID
Q8WXH5
retrieved
20 March 2016
language of work or name
English
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