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Left-right determination factor 1
mammalian protein found in Homo sapiens
left-right determination factor B
protein lefty-B
protein lefty-1
left-right determination factor 1
LEFTY1
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O75610
subclass of
protein
1 reference
stated in
UniProt
retrieved
1 December 2016
UniProt protein ID
O75610
part of
Left- Right determination factor
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O75610
Cystine-knot cytokine
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O75610
Transforming growth factor-beta, C-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
TGF-beta, propeptide family
1 reference
based on heuristic
inferred from protein domain or family
Transforming growth factor beta, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O75610
encoded by
LEFTY1
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O75610
molecular function
transforming growth factor beta receptor binding
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IBA
cytokine activity
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O75610
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IBA
growth factor activity
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O75610
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IEA
cell component
extracellular region
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O75610
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IEA
extracellular space
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O75610
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IBA
biological process
regulation of apoptotic process
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IBA
multicellular organism development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O75610
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IEA
positive regulation of pathway-restricted SMAD protein phosphorylation
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IBA
heart morphogenesis
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
ISS
determination of left/right symmetry
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
ISS
negative regulation of transcription by RNA polymerase II
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
ISS
transforming growth factor beta receptor signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
TAS
regulation of MAPK cascade
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IBA
SMAD protein signal transduction
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IBA
cell development
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IBA
BMP signaling pathway
determination method
IBA
1 reference
retrieved
27 February 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75610&geneProductId=UniProtKB:O75610
determination method
IBA
regulation of signaling receptor activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75610
determination method
IEA
has part(s)
Transforming growth factor beta, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O75610
Transforming growth factor-beta, C-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O75610
TGF-beta, propeptide
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O75610
Identifiers
RefSeq protein ID
NP_066277
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
10637
UniProt protein ID
O75610
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O75610
Ensembl protein ID
ENSP00000272134
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000272134
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