(Q21173451)

http://www.ebi.ac.uk/interpro/protein/P27544

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

TRAM/LAG1/CLN8 homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

sphingosine N-acyltransferase activity

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27544&geneProductId=UniProtKB:P27544

10 September 2018

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27544&geneProductId=UniProtKB:P27544

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27544&geneProductId=UniProtKB:P27544

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

intracellular membrane-bounded organelle

IEA

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27544&geneProductId=UniProtKB:P27544

ISS

endoplasmic reticulum

3 references

16 July 2018

16 July 2018

(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27544&geneProductId=UniProtKB:P27544

16 July 2018

Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27544&geneProductId=UniProtKB:P27544

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

endoplasmic reticulum

4 references

8 April 2019

8 April 2019

(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

8 April 2019

Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

cellular response to mycotoxin

IBA

biological process

1 reference

8 April 2019

Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

cellular response to UV-A

1 reference

8 April 2019

Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

cellular response to dithiothreitol

1 reference

8 April 2019

Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

negative regulation of telomerase activity

1 reference

8 April 2019

Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

ceramide biosynthetic process

IEA

6 references

16 July 2018

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27544&geneProductId=UniProtKB:P27544

16 July 2018

Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27544&geneProductId=UniProtKB:P27544

16 July 2018

2-Hydroxy-ceramide synthesis by ceramide synthase family: enzymatic basis for the preference of FA chain length

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27544&geneProductId=UniProtKB:P27544

16 July 2018

Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27544&geneProductId=UniProtKB:P27544

16 July 2018

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27544&geneProductId=UniProtKB:P27544

16 July 2018

Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27544&geneProductId=UniProtKB:P27544

sphingolipid biosynthetic process

ceramide biosynthetic process

TAS

7 references

8 April 2019

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

8 April 2019

2-Hydroxy-ceramide synthesis by ceramide synthase family: enzymatic basis for the preference of FA chain length

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

8 April 2019

Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

8 April 2019

Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

8 April 2019

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

8 April 2019

Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27544

TRAM/LAG1/CLN8 homology domain

IBA

has part(s)

1 reference

stated in

InterPro Release 71.0