(Q24307846)

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Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1

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Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1 (English)

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Ceramide synthase 1

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GOA release 2020-03-11

negative regulation of telomerase activity

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GOA release 2020-03-11

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based on heuristic

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author name string

Leslie G Wooten-Blanks

1

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Pengfei Song

2

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Can E Senkal

3

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Besim Ogretmen

4

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language of work or name

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publication date

October 2007

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21

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12

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3386-97

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The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells

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https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

The modification of Sp3 isoforms by SUMOylation has differential effects on the SRC1A promoter

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

The ins and outs of sphingolipid synthesis

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https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

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Telomerase maintains telomere structure in normal human cells.

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https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Creation of human tumour cells with defined genetic elements

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Raft ceramide in molecular medicine

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of E2F1 activity by acetylation

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Acetylation: a regulatory modification to rival phosphorylation?

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcription factor Sp3 is regulated by acetylation

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor necrosis factor-alpha inhibits hTERT gene expression in human myeloid normal and leukemic cells

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

Substrate specificity of human ceramide kinase

1 reference

https://api.crossref.org/works/10.1096%2FFJ.07-8621COM

7 January 2021

based on heuristic

inferred from DOI database lookup

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