(Q21173956)

http://www.ebi.ac.uk/interpro/protein/Q9NZC2

Immunoglobulin-like domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZC2

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

Immunoglobulin V-set domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

scaffold protein binding

1 reference

9 May 2019

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

lipopolysaccharide binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

lipoteichoic acid binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

peptidoglycan binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

1 reference

9 May 2019

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

signaling receptor activity

1 reference

1 January 2018

Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZC2&geneProductId=UniProtKB:Q9NZC2

1 reference

9 May 2019

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

high-density lipoprotein particle binding

1 reference

9 May 2019

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

1 reference

9 May 2019

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

low-density lipoprotein particle binding

1 reference

9 May 2019

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

apolipoprotein binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

apolipoprotein A-I binding

1 reference

9 May 2019

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

very-low-density lipoprotein particle binding

1 reference

9 May 2019

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

signaling receptor activity

3 references

8 April 2019

Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

8 April 2019

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

protein-containing complex binding

1 reference

9 May 2019

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

lipoprotein particle binding

1 reference

9 May 2019

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

3 references

9 May 2019

A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

9 May 2019

Intracellular trafficking of TREM2 is regulated by presenilin 1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

9 May 2019

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

8 April 2019

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

integral component of plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

intrinsic component of plasma membrane

1 reference

9 May 2019

TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

9 May 2019

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

9 May 2019

Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

9 May 2019

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

9 May 2019

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

dendritic cell differentiation

biological process

1 reference

9 May 2019

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of CD40 signaling pathway

1 reference

9 May 2019

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of calcium-mediated signaling

1 reference

9 May 2019

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of C-C chemokine receptor CCR7 signaling pathway

1 reference

9 May 2019

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

phagocytosis, engulfment

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

detection of peptidoglycan

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

humoral immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

cellular response to lipoteichoic acid

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of protein localization to plasma membrane

1 reference

9 May 2019

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

regulation of immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

9 May 2019

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

detection of lipoteichoic acid

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

innate immune response

1 reference

9 May 2019

detection of lipopolysaccharide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

cellular response to peptidoglycan

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of antigen processing and presentation of peptide antigen via MHC class II

1 reference

9 May 2019

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of ERK1 and ERK2 cascade

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZC2&geneProductId=UniProtKB:Q9NZC2

regulation of plasma membrane bounded cell projection organization

positive regulation of protein secretion

1 reference

9 May 2019

FRMD4A-cytohesin signaling modulates the cellular release of tau.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

microglial cell activation

IMP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

negative regulation of interleukin-1 beta production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

negative regulation of tumor necrosis factor production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of interleukin-10 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

negative regulation of apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of osteoclast differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of ERK1 and ERK2 cascade

3 references

9 May 2019

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

9 May 2019

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of NIK/NF-kappaB signaling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

microglial cell activation involved in immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

defense response to bacterium

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

regulation of innate immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

microglial cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

amyloid-beta clearance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

complement-mediated synapse pruning

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

neuroinflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of neuroinflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of engulfment of apoptotic cell

1 reference

9 May 2019

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

positive regulation of microglial cell activation

IMP

3 references

9 May 2019

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

9 May 2019

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2

immunoglobulin V-set domain

has part(s)

1 reference

stated in

InterPro Release 71.0