(Q21174279)

Kelch-type beta propeller

1 reference

BTB-kelch protein

1 reference

BTB/POZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

BTB/Kelch-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Kelch repeat type 1, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

4 references

8 April 2019

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

structural molecule activity

IPI

1 reference

8 April 2019

Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

ubiquitin-protein transferase activity

TAS

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UH77&geneProductId=UniProtKB:Q9UH77

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

Cul3-RING ubiquitin ligase complex

IEA

3 references

8 April 2019

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UH77&geneProductId=UniProtKB:Q9UH77

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UH77&geneProductId=UniProtKB:Q9UH77

27 February 2018

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UH77&geneProductId=UniProtKB:Q9UH77

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

protein K48-linked ubiquitination

IBA

biological process

1 reference

27 February 2018

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UH77&geneProductId=UniProtKB:Q9UH77

distal tubule morphogenesis

IDA

3 references

8 April 2019

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

renal sodium ion absorption

IMP

3 references

27 February 2018

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UH77&geneProductId=UniProtKB:Q9UH77

27 February 2018

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UH77&geneProductId=UniProtKB:Q9UH77

27 February 2018

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UH77&geneProductId=UniProtKB:Q9UH77

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

IMP

protein ubiquitination

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

post-translational protein modification

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

3 references

8 April 2019

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

renal sodium ion absorption

IBA

4 references

8 April 2019

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

1 reference

8 April 2019

Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UH77

1 reference

Kelch repeat type 1

1 reference

BTB/POZ domain

1 reference