(Q21201832)

English

Filaggrin

mammalian protein found in Homo sapiens

epidermal filaggrin
FLG
filaggrin

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20930

EF-hand domain pair

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20930

EF-hand domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

S-100, protein family

1 reference

based on heuristic

inferred from protein domain or family

S100/CaBP-9k-type, calcium binding, subdomain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EF-Hand 1, calcium-binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

S100/Calbindin-D9k, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

calcium ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

protein binding

determination method

1 reference

8 April 2019

Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

transition metal ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

structural constituent of skin epidermis

determination method

1 reference

17 October 2017

The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20930&geneProductId=UniProtKB:P20930

determination method

structural constituent of skin epidermis

determination method

2 references

8 April 2019

The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

intermediate filament

determination method

1 reference

8 April 2019

Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

keratohyalin granule

determination method

2 references

17 October 2017

Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S-100-like calcium binding domain at the amino terminus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20930&geneProductId=UniProtKB:P20930

determination method

17 October 2017

Analysis of epidermal-type transglutaminase (transglutaminase 3) in human stratified epithelia and cultured keratinocytes using monoclonal antibodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20930&geneProductId=UniProtKB:P20930

determination method

intracellular membrane-bounded organelle

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

determination method

1 reference

17 October 2017

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20930&geneProductId=UniProtKB:P20930

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

cornified envelope

determination method

1 reference

17 October 2017

The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20930&geneProductId=UniProtKB:P20930

determination method

cornified envelope

determination method

2 references

8 April 2019

The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

determination method

1 reference

8 April 2019

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

keratohyalin granule

determination method

3 references

8 April 2019

Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S-100-like calcium binding domain at the amino terminus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

8 April 2019

Analysis of epidermal-type transglutaminase (transglutaminase 3) in human stratified epithelia and cultured keratinocytes using monoclonal antibodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

collagen-containing extracellular matrix

determination method

1 reference

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

biological process

keratinocyte differentiation

determination method

1 reference

8 April 2019

Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

establishment of skin barrier

determination method

1 reference

17 October 2017

Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20930&geneProductId=UniProtKB:P20930

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

peptide cross-linking

determination method

1 reference

8 April 2019

The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20930

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20930

EF-hand 1, calcium-binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20930

S100/Calbindin-D9k, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20930

S100/CaBP-9k-type, calcium binding, subdomain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20930

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20930

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000357789

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000357789

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

21 March 2016

language of work or name

Sitelinks

Wikipedia(13 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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