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(Q21494340)
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Cystin 1
mammalian protein found in Mus musculus
congenital polycystic kidneys
Cys1
cilia-associated protein
cystin-1
cystin cilia associated protein
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q8R4T1
part of
membrane protein
1 reference
based on heuristic
inferred from GOA cell component → membrane
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q8R4T1
encoded by
Cys1
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q8R4T1
molecular function
DNA-binding transcription activator activity, RNA polymerase II-specific
determination method
IDA
2 references
retrieved
10 September 2018
stated in
The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R4T1&geneProductId=UniProtKB:Q8R4T1
determination method
IDA
retrieved
14 February 2019
stated in
The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IDA
chromatin binding
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IDA
RNA polymerase II cis-regulatory region sequence-specific DNA binding
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IDA
protein binding
determination method
IPI
1 reference
retrieved
14 February 2019
stated in
The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IPI
transcription corepressor activity
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IDA
cell component
cytoplasm
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8R4T1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IEA
ciliary basal body
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IDA
cytosol
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IDA
cell projection
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8R4T1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IEA
membrane
determination method
IDA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8R4T1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IEA
retrieved
14 February 2019
stated in
The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IDA
plasma membrane
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8R4T1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IEA
cilium
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8R4T1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IEA
ciliary membrane
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8R4T1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IEA
membrane raft
determination method
IDA
1 reference
retrieved
31 January 2018
stated in
Cystin localizes to primary cilia via membrane microdomains and a targeting motif
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R4T1&geneProductId=UniProtKB:Q8R4T1
determination method
IDA
axoneme
determination method
IDA
IMP
3 references
retrieved
31 January 2018
stated in
Cystin localizes to primary cilia via membrane microdomains and a targeting motif
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R4T1&geneProductId=UniProtKB:Q8R4T1
determination method
IMP
retrieved
31 January 2018
stated in
Cystin localizes to primary cilia via membrane microdomains and a targeting motif
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R4T1&geneProductId=UniProtKB:Q8R4T1
determination method
IDA
retrieved
31 January 2018
stated in
Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R4T1&geneProductId=UniProtKB:Q8R4T1
determination method
IDA
cytoskeleton
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8R4T1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IEA
nucleus
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IDA
axoneme
determination method
IDA
2 references
retrieved
14 February 2019
stated in
Cystin localizes to primary cilia via membrane microdomains and a targeting motif
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IDA
retrieved
14 February 2019
stated in
Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IDA
biological process
kidney development
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IMP
negative regulation of DNA-binding transcription factor activity
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IDA
inner ear development
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
The molecular and structural basis of hearing impairment in mice with the cpk mutant gene
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IMP
positive regulation of transcription by RNA polymerase II
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IDA
transcription by RNA polymerase II
determination method
IEA
1 reference
retrieved
31 January 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R4T1&geneProductId=UniProtKB:Q8R4T1
determination method
IEA
negative regulation of transcription by RNA polymerase II
determination method
IEA
1 reference
retrieved
31 January 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R4T1&geneProductId=UniProtKB:Q8R4T1
determination method
IEA
negative regulation of nucleic acid-templated transcription
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4T1
determination method
IEA
Identifiers
RefSeq protein ID
NP_001004455
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
12879
NP_001155279
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
12879
NP_619627
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
12879
XP_006515015
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
12879
UniProt protein ID
Q8R4T1
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q8R4T1
Ensembl protein ID
ENSMUSP00000073796
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000073796
ENSMUSP00000126787
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000126787
ENSMUSP00000133902
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000133902
ENSMUSP00000134522
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000134522
ENSMUSP00000134701
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000134701
ENSMUSP00000140759
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000140759
ENSMUSP00000141121
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000141121
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